نتایج جستجو برای: ژن igf
تعداد نتایج: 32039 فیلتر نتایج به سال:
PURPOSE The aim of this study was to characterize the relationship of insulin-like growth factor (IGF)-II expression with IGF-I, IGF-I receptor (IGF-IR), cyclooxygenase-2 (COX-2), and matrix metalloproteinase (MMP)-7 in early colorectal carcinogenesis. EXPERIMENTAL DESIGN With the semiquantitative reverse transcriptase-PCR, 90 human colorectal tumor tissues (63 adenomas and 27 submucosal pT1 ...
هورمون رشد و عامل رشد شبه انسولینی 1، از هورمون های آنابولیک هستند که نقش حیاتی در بالیدگی دستگاه های مختلف بدنی به ویژه در کودکی و نوجوانی دارند. ورزش یکی از محرک هایی است که ترشحgh و igf-1 را تحت تأثیر قرار می دهد، امروزه ورزش های آبی به علت ایجاد نشاط در کودکان، بسیار توصیه شده است. هدف این پژوهش بررسی اثر یک دورة 8 هفته ای تمرین در آب بر سطوح استراحتی ghو igf-1 کودکان 9 تا 11 سال پسر است. 1...
Using affinity cross-linking techniques, we report the presence of type I IGF and type II IGF receptors in Madin-Darby canine kidney cells, a line of cells lacking insulin receptors. The IGF receptors were further characterized by competition binding studies and found to be similar to IGF receptors in other tissue types. In Madin-Darby canine kidney cells, the type I IGF receptor binds IGF-I gr...
PURPOSE Growth factors, particularly insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) in some nonendocrine and a few endocrine tumors, are thought important in recurrence, growth, and aggressiveness. Whether this is true of neuroendocrine tumors such as gastrinomas is unclear. The aim of this study was to address this question in gastrinomas. EXPERIMENTAL DESIGN IGF-I and IGF-...
Downlo type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two ellular α subunits and two β subunits with tyrosine kinase activity. The IGF-1R is frequently upregulated cers and signals from the cell surface to promote proliferation and cell survival. Recent attention has d on the IGF-1R as a target for cancer treatment. Here, we report that the nucle...
BACKGROUND Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy. Constitutive PI3K activation, reflecting an intrinsic oncogenic deregulation of primary blast cells, is detected in 50% of patients with acute myeloid leukemia. However, the mechanisms leading to this activation are current...
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenic signal through both IGF-IR and an alternately spliced form of the insulin receptor (IR-A), neutralizing the biological activity of this growth factor directly is a potential alternative option to IGF...
CONTEXT The TSH receptor (TSHR) is considered the main target of stimulatory autoantibodies in the pathogenesis of Graves' ophthalmopathy (GO); however, it has been suggested that stimulatory IGF-1 receptor (IGF-1R) autoantibodies also play a role. OBJECTIVE We previously demonstrated that a monoclonal stimulatory TSHR antibody, M22, activates TSHR/IGF-1R cross talk in orbital fibroblasts/pre...
Wharton’s jelly mesenchymal stem cells (HWJMSCs) hold promise for myocardial regeneration, but optimal treatment regimen (preferably with a growth factor) is required to maximize functional benefits. The aim of this study was to explore the cardioprotective and angiogenesis effects of HWJMSCs combined with insulin-like growth factor-1 (IGF-1) in the treatment of acute myocardial infarction. Th...
In the present study the effect of initial weight on IGF-1 gene expression in breast muscle of Japanese quail was investigated using completely randomized design. Two hundred pieces birds were randomly divided into two different groups including light and heavy weight. IGF-1 gene expression levels were measured using the Real time PCR techniques in breast muscle of the Japanese quail at 24...
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