We determined the contribution of vascular large conductance Ca2+-activated K+ (BK) and L-type Ca2+ channel dysregulation to exaggerated mortality in cecal ligation/puncture (CLP)-induced septic BK channel β1-subunit knockout (BK β1-KO, smooth muscle specific) mice. CLP-induced hemodynamic changes and mortality were assessed over 7 days in wild-type (WT) and BK β1-KO mice that were either untre...

We previously revealed that the anti-proliferative activity of 25-hydroxyvitamin D3 (25(OH)D3) in human prostate PZ-HPV-7 cells depends on direct action 25(OH)D3 through vitamin D receptor (VDR). then attempted to confirm vivo using Cyp27b1 knockout (KO) mice. Daily administration at 250 μg/kg bw/day rescued rachitic conditions KO The plasma levels calcium, phosphorus, and parathyroid hormonea ...

Mannose binding lectin (MBL) is a protein of the collectin family that appears important in resistance to invasive pulmonary aspergillosis. We assessed the role of MBL in experimental systemic aspergillosis. MBL-sufficient C57BL/6 (WT) mice and B6.129S4--Mb11(tm1Kata) Mb12(tm1Kata)/J MBL A and C gene-knockout (KO) mice were infected intravenously with different inocula of Aspergillus fumigatus ...

Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib has been approved for treatment of advanced ovarian cancer associated with BRCA1 and BRCA2 mutations. BRCA1- and BRCA2-mutated cells, which are homologous recombination (HR) deficient, are hypersensitive to PARPi through the mechanism of synthetic lethality. Here we examine the effect of PARPi on HR-proficient cells. Olaparib pretre...

We define homological dimensions for S-algebras, the generalized rings that arise in algebraic topology. We compute the homological dimensions of a number of examples, and establish some basic properties. The most difficult computation is the global dimension of real K-theory KO and its connective version ko at the prime 2. We show that the global dimension of KO is 2 or 3, and the global dimen...