نتایج جستجو برای: ژن myh9
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were most notable in large-sized platelet subpopulations. The implication is that the bleeding tendency in these disorders is secondary to abnormal in vivo platelet-vessel wall and platelet-platelet interactions caused by decreased levels of GPIb-VIX. An interesting finding given the necessary interconnection between cytoskeletal components and membrane proteins. This suggested mechanism deserv...
Idiopathic membranous nephropathy (MN) is one common cause of idiopathic nephrotic syndrome in adults; 25% of MN patients proceed to end-stage renal disease. In adults, membranous nephropathy is a lead cause of nephrotic syndrome, with about 75% of the cases idiopathic. Secondary causes include autoimmune disease, infection, drugs and malignancy. Three hypotheses about pathogenesis have surface...
Lipid droplets (LDs) are cellular organelles specialized in triacylglycerol (TG) storage undergoing homotypic clustering and fusion. In non-adipocytic cells with numerous LDs this is balanced by poorly understood droplet dissociation mechanisms. We identify non-muscle myosin IIa (NMIIa/MYH-9) and formin-like 1 (FMNL1) in the LD proteome. NMIIa and actin filaments concentrate around LDs, and for...
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