Matrix metalloproteinase-1 (MMP-1) plays an important role in fibrolysis by degrading excessively deposited collagen I and III. We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways. In the current study, we attempted to further explore the molecular mechanisms involved in the regulation of MMP-1. We ...

BACKGROUND AND AIMS Elevated circulating concentrations of the hormone gastrin contribute to the development of gastric adenocarcinoma and types-1 and 2 gastric neuroendocrine tumors (NETs). MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate proteins which in turn influence various biological processes. We hypothesised that gastrin induces the expression of specif...

Professor P.T. Blythe Director: Transport Operations Research Group Cassie Building, University of Newcastle upon Tyne UK, NE1 7RU Tel +44 191-222-7935 Fax +44-191-222-8352 [email protected] and Dr Alan Tully School Of Computing Science University of Newcastle upon Tyne, UK and Paul Knight (Regional Director) Faber Maunsell Ltd, UK And Dr John Walker (Technical Consultant) Thales Telecom Ser...

The 2.1-A resolution crystal structure of wild-type green fluorescent protein and comparison of it with the recently determined structure of the Ser-65 --> Thr (S65T) mutant explains the dual wavelength absorption and photoisomerization properties of the wild-type protein. The two absorption maxima are caused by a change in the ionization state of the chromophore. The equilibrium between these ...

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero, Seocho-Gu, Seoul, Korea Correspondence to: Hyung Joo Park. Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero, Seocho-Gu, Seoul, Korea. Email: hyjpar...

PURPOSE MicroRNAs (miRNAs) regulate various cellular functions, including development, cell proliferation, apoptosis, and tumorigenesis. Different signatures associated with various tissue types, diagnosis, progression, prognosis, staging, and treatment response have been identified by miRNA expression profiling of human tumors. miRNAs function as oncogenes or as tumor suppressors. The relation...

BACKGROUND Ultrafine particles (<100 nm) are ubiquitous present in the air and may contribute to adverse cardiovascular effects. Exposure to air pollutants can alter miRNA expression, which can affect downstream signaling pathways. miRNAs are present both in the intracellular and extracellular environment. In adults, miR-222 and miR-146a were identified as associated with particulate matter exp...

Objetivo: avaliar a qualidade dos PGRSS de estabelecimentos prestadores serviços da saúde, tomando como base RDC n° 222/2018 ANVISA. Material e Métodos: os foram buscados na internet (buscas livres contatos com estabelecimentos) analisados (checklist) quanto presença quinze itens constantes 222/2018. Resultados: 20 não estavam vinculados aos sites oficiais houve dificuldade retorno em e-mails e...

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