Phenobarbital and other xenobiotics induce drug-metabolizing enzymes, including glutathione S-transferase A1/A2 (rGSTA1/A2). We examined the mechanism of induction of rGSTA1/A2 in rat livers after phenobarbital treatment. The induction of rGSTA1/A2 was not uniform across the hepatic lobule; steady-state transcript levels were threefold higher in perivenous hepatocytes relative to periportal hep...

Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in children. In contrast to the RSV prototypic strain A2, clinical isolate RSV 2-20 induces airway mucin expression in mice, a clinically relevant phenotype dependent on the fusion (F) protein of the RSV strain. Epidermal growth factor receptor (EGFR) plays a role in airway mucin expression in other sy...

Several functional tests were performed to compare Hb A, Hb A2, and Hb Lepore Boston, which has a delta-beta crossover in the region of residues 87 to 116. Oxygen equilibrium curves determined by an automatic apparatus in 0.1 M potassium phosphate buffer, pH 7.0, at 20 degrees showed that the p50 was 5.8 mm Hg for Hb Lepore Boston, in contrast to 8.1 and 10.3 mm Hg for Hb A2 and Hb A, respectiv...

We have previously demonstrated that plasmin acts as a potent proinflammatory activator of human peripheral monocytes. Here we identify the annexin A2 heterotetramer, composed of annexin A2 and S100A10, as a receptor for the plasmin-induced signaling in human monocytes. Monocytes express the annexin A2 heterotetramer on the cell surface as shown by flow cytometry, fluorescence microscopy, and c...

We show that the braided tensor product algebra A1⊗A2 of two module algebras A1,A2 of a quasitriangular Hopf algebraH is equal to the ordinary tensor product algebra of A1 with a subalgebra of A1⊗A2 isomorphic to A2, provided there exists a realization of H within A1. In other words, under this assumption we construct a transformation of generators which ‘decouples’ A1,A2 (i.e. makes them commu...

Let G be a Jordan domain and K C G be relatively closed with Area(K) = 0. Let A2(G\K) and A2 (G) be the Bergman spaces on G\K, respectively G and define N = A2(G\K) e A2 (G). In this paper we show that with a mild restriction on K, every function in N has an analytic continuation across the analytic arcs of 8G that do not intersect K. This result will be used to discuss the Fredholm theory of t...

Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells. To elucidate the cause of abnormal expression of annexin A2, Western blotting, immunoproteomics and immunohistochemical staining were performed to analyze differentially ubiquitinated proteins between fresh breast cancer tissue and its adjacent normal breast tissue from five female volunteers. We detec...

Let C1 and C2 be algebraic plane curves in C such that the curves intersect in d1 · d2 points where d1, d2 are the degrees of the curves respectively. Oka and Sakamoto proved that π1(C \ C1 ∪ C2)) ∼= π1(C \ C1)× π1(C \ C2) [1]. In this paper we prove the converse of Oka and Sakamoto’s result for line arrangements. Let A1 and A2 be non-empty arrangements of lines in C such that π1(M(A1 ∪ A2)) ∼=...