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Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, with most patients facing an adverse clinical outcome. Aberrant Notch pathway activation has been implicated in the initiation and progression of PDAC, specifically the aggressive phenotype of the disease. We used a panel of human PDAC cell lines as well as patient-derived PDAC xenografts to determine whether pharmacologic targetin...
We extend to a degenerate case result by B. Malgrange on integrable deformations of irregular singularities, inspired Cotti, Dubrovin and Guzzetti (Local moduli semisimple Frobenius coalescent structures, SIGMA Symmetry Integrability Geom. Methods Appl. 16 (2020), paper no. 040). give an application some meromorphic connections in Birkhoff normal form the construction manifolds.
PURPOSE Sprint- (≤1.8 km) and distance-skiing (≥15 km) performance rely heavily on aerobic capacity. However, in sprint skiing, due to the ~20% higher speed, anaerobic capacity contributes significantly. This study aimed to identify the possible anthropometric and physiological differences between elite male sprint and distance skiers. METHODS Six sprint and 7 distance international-level cro...
BACKGROUND 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors have several pleiotropic effects, including anti-inflammatory properties, and are reported to improve endothelial functions. Pathophysiologically, acute lung injury (ALI) is caused by a severe inflammatory response and endothelial dysfunction. OBJECTIVE To investigate the effects of simvastatin (an HMG-CoA reduct...
BACKGROUND The Acute Respiratory Distress Syndome (ARDS) Network low tidal volume (VT) trial paved the ground for mechanically ventilating ARDS patients with a VT of 6 mL/kg ideal body weight (IBW). Although there is no consensus that a low VT is advantageous in non-ARDS patients,it is accepted that high VT should be avoided. Because compliance rates with ventilator recommendations are 30%, the...
Pharmacokinetics of 8 doses of rituximab (375 mg/m(2)) given in combination with 2-week cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone/prednisolone (CHOP-14) was determined by ELISA in 20 elderly patients with diffuse large B-cell lymphoma (DLBCL) 10 minutes before and after each infusion and 1 week and 1, 2, 3, 6, and 9 months after the last infusion. Population pharmacokin...
BACKGROUND Obesity in adults is associated with increased left ventricular (LV) mass. The mechanism for this is unclear, however. We tested the hypothesis that insulin resistance is an important independent contributing factor to LV mass in the healthy obese population. METHODS AND RESULTS The study population consisted of 40 normotensive, nondiabetic, otherwise healthy obese subjects with bo...
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