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INTRODUCTION: Osteoclasts are multinucleated, specialized cells responsible for bone resorption and play important roles in the maintenance of normal bone structure and function. At least dozens of genes have been shown to positively and negatively regulate osteoclastogenesis and osteoclast activation.TRAP and cathepsin K are the two mail enzymes responsible for the degradation of bone mineral ...
Purpose: Official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG). Due to their rarity and their heterogeneous histopathology uterine sarcomas remain challenging tumors to manage and need a multidisciplinary approach. To our knowledge so far there is no evidence-based guideline on the appropiate management of these heterogeneous tumors. Methods: Thi...
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