نتایج جستجو برای: 1 although vcam

تعداد نتایج: 3214491  

Journal: :Physiological research 2010
L Bosanská D Michalský Z Lacinová I Dostálová M Bártlová D Haluzíková M Matoulek M Kasalický M Haluzík

Increased circulating adhesion molecules in patients with obesity play an important role in the development of endothelial dysfunction/atherosclerosis. The aim of this study was to assess the contribution of various fat depots to the production of adhesion molecules in obesity. 12 women with first and second degree of obesity, 13 women with third degree of obesity and 14 lean age-matched women ...

Journal: :Journal of vascular research 2012
Jacqueline Ohanian Simon P Forman Gideon Katzenberg Vasken Ohanian

Endothelin-1 (ET-1) stimulates vascular cell adhesion molecule (VCAM-1) expression, a process associated with arterial remodelling. However, the pathways activated by ET-1 that lead to VCAM-1 expression are not fully understood. It is reported that sphingomyelinases are necessary for VCAM-1 expression in response to cytokines. Our aim was to investigate the role of sphingomyelinases in ET-1-ind...

Journal: :Blood 1993
B N Dittel J B McCarthy E A Wayner T W LeBien

Self-renewal and differentiation of B-cell precursors is dependent on interactions with bone marrow (BM) stromal cells and associated extracellular matrix. We have recently developed an interleukin (IL)-7-dependent, BM-derived stromal cell culture that supports the growth of normal human B-cell precursors. In the current study, we have characterized the constitutive expression, cytokine-regulat...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 1999
C D Collard A Agah W Reenstra J Buras G L Stahl

We have previously shown that reoxygenation of hypoxic human umbilical vein endothelial cells (HUVECs) leads to the activation and deposition of complement. In the present study, we investigated whether the terminal complement complex (C5b-9) influences HUVEC nuclear factor-kappaB (NF-kappaB) translocation and vascular cell adhesion molecule-1 (VCAM-1) protein expression after hypoxia/reoxygena...

2013
Jian Tu Zhiqiang Hu Zhongbin Chen

Radiosurgery for cerebral arteriovenous malformations (AVMs) is limited to 2-year latency. There is no early marker to monitor whether the lesion is responsive to radiosurgery. In this study, we examined endothelial gene expression and molecular changes in response to radiosurgery. Gene expression of E- and P-selectin, ICAM-1, PECAM-1, VCAM-1, tissue factor, and vWF in human cerebral microvascu...

Journal: :Blood 2006
M Asif Amin Christian S Haas Kui Zhu Pamela J Mansfield Michael J Kim Nicholas P Lackowski Alisa E Koch

Cell adhesion molecules are critical in monocyte (MN) recruitment in immune-mediated and hematologic diseases. We investigated the novel role of recombinant human migration inhibitory factor (rhMIF) in up-regulating vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) and their signaling pathways in human MNs. rhMIF-induced expression of VCAM-1 and ICAM-1 wa...

2013
Ming-Li Yuan Zhao-Hui Tong Xiao-Guang Jin Jian-Chu Zhang Xiao-Juan Wang Wan-Li Ma Wen Yin Qiong Zhou Hong Ye Huan-Zhong Shi

BACKGROUND Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been demonstrated to be expressed on pleural mesothelial cells (PMCs), and to mediate leukocyte adhesion and migration; however, little is known about whether adhesion molecule-dependent mechanisms are involved in the regulation of CD4(+) T cells by PMCs in tuberculous pleural effusion (TPE...

Journal: :Blood 1991
T Carlos N Kovach B Schwartz M Rosa B Newman E Wayner C Benjamin L Osborn R Lobb J Harlan

Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium by cytokines. We examined the contribution of these adhesive proteins to human peripheral blood monocyte adherence to endothelium using transfected Chinese hamster ovary (CHO) cells stably expressing these proteins and monoclonal antibodies (MoAbs) to EL...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Bin Liang Xin Wang Nana Zhang Huiyu Yang Rui Bai Ming Liu Yunfei Bian Chuanshi Xiao Zhiming Yang

BACKGROUND/AIMS Atherosclerosis is a chronic inflammatory disease. Intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) play important roles in inflammatory processes. P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB signaling regulate ICAM-1, VCAM-1, and MCP-1 expression. Angiotensin (An...

2012
Javier Triñanes Eduardo Salido Julián Fernández Margarita Rufino José Manuel González-Posada Armando Torres Domingo Hernández

OBJECTIVE Diabetes may accelerate atheromatosis in uremic patients. Our aim was to assess the influence of type 1 diabetes on the atheromatosis-related inflammation in patients with chronic kidney disease (CKD). RESEARCH DESIGN AND METHODS We analyzed the expression of proinflammatory cytokines and adhesion molecules in the inferior epigastric artery walls of type 1 diabetic patients with CKD...

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