نتایج جستجو برای: 1 antitrypsin a1at

تعداد نتایج: 2753541  

Journal: :Translational Gastroenterology and Hepatology 2021

Journal: :Frontiers in Pharmacology 2021

Journal: :European Respiratory Journal 2014

Journal: :Journal of Clinical Pathology 1981

Journal: :Respiratory Research 2005
Marina Gorrini Anna Lupi Paolo Iadarola Conceição Dos Santos Paola Rognoni Daniele Dalzoppo Natalia Carrabino Ernesto Pozzi Aldo Baritussio Maurizio Luisetti

BACKGROUND Alpha1-antitrypsin and surfactant protein-A (SP-A) are major lung defense proteins. With the hypothesis that SP-A could bind alpha1-antitrypsin, we designed a series of in vitro experiments aimed at investigating the nature and consequences of such an interaction. METHODS AND RESULTS At an alpha1-antitrypsin:SP-A molar ratio of 1:1, the interaction resulted in a calcium-dependent d...

Journal: :The Journal of Cell Biology 1987
H F Lodish N Kong S Hirani J Rasmussen

We have identified a vesicle fraction that contains alpha 1-antitrypsin and other human HepG2 hepatoma secretory proteins en route from the rough endoplasmic reticulum (RER) to the cis face of the Golgi complex. [35S]Methionine pulse-labeled cells were chased for various periods of time, and then a postnuclear supernatant fraction was resolved on a shallow sucrose-D2O gradient. This intermediat...

Journal: :The Journal of clinical investigation 1981
J E Gadek G A Fells R L Zimmerman S I Rennard R G Crystal

The current concepts of the pathogenesis of emphysema hold that progressive, chronic destruction of the alveolar structures occurs because there was in imbalance between the proteases and antiproteases in the lower respiratory tract. In this context, proteases, particularly neutrophil elastase, work unimpeded to destroy the alveolar structures. This concept has evolved from consideration of pat...

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