Ang II has been involved in the pathogenesis of cardiovascular diseases, and matrix metalloproteinase-9 (MMP-9) induced migration of human aortic smooth muscle cells (HASMCs) is the most common and basic pathological feature. Carbon monoxide (CO), a byproduct of heme breakdown by heme oxygenase, exerts anti-inflammatory effects in various tissues and organ systems. In the present study, we aime...

Tubuloglomerular feedback (TGF) is the mechanism by which the macula densa (MD) senses increases in luminal NaCl concentration and sends a signal to constrict the afferent arteriole (Af-Art). The kidney expresses constitutively heme oxygenase-2 (HO-2) and low levels of HO-1. HOs release carbon monoxide (CO), biliverdin, and free iron. We hypothesized that renal HOs inhibit TGF via release of CO...

This article describes in extended detail the methodology applied for acquisition of transcriptomic data, and subsequent statistical data modelling, published by Wilson et al. (2015) in a study of the effects of carbon monoxide-releasing molecule-3 (CORM-3 [Ru(CO)3Cl(glycinate)]) on heme-deficient bacteria. The objective was to identify non-heme targets of CORM action. Carbon monoxide (CO) inte...

Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-induced apoptosis in the mouse intestinal epithelial cell line, MODE-K. In the ...

Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, antiinflammatory and anti-apoptotic effects. COreleasing molecules (CO-RMs) have therapeutic value, increasing phagocytosis and reducing sepsis-induced lethality. Here we identify for the first time the bacterial targets of CORM-3, Ru(CO)3Cl(glycinate), a ruthenium-based carbonyl that liberates CO rapidly under physio...

this research was conducted on determination of better planting distance and better amount of nitrogen and phosphorus for hybrid rice (bahar 1). planting distance were used in this experiment, include 30×15, 30×20 and 30×25 cm as main factor. and also nitrogen fertilizer was used, include four levels, 65, 95, 125 and 155 k/ha and phosphorus fertilizer used include tow levels, 50 and 100 k/ha as...

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in chemistry and biomedicine. CORMs kill bacteria culture animal models, but reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru2Cl4(CO)6), the first widely commercially available CORM, displays numerous pharmacological, biochemical microbiological a...

in order to determine the best planting date and seeding rate of two triticale genotype in mashhad climate condition on 2007-2009 growing season, an experiment was carried out, using a split-plot design based on randomized complete block design with three replication, at torogh agricultural research station, mashhad, iran. main plots devoted to five seeding dates and factorial combination of th...

The objective of the present study is to investigate the effects of irrigation water salinity,cow manure levels and different planting methods on ions variation in soil and their uptake bysaffron. A split-split plot arrangement was conducted in a randomized complete block designwith irrigation water salinity levels (0.45 (fresh water, S1), 1.0 (S2), 2.0 (S3) and 3.0 (S4) dS m-1)as the main plot...