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مقدمه: التهاب سیستمی و التهاب عروقی دو عامل خطرزا در ایجاد نفروپاتی دیابتی هستند. در بیماران دیابتی، غلظت عوامل التهاب سیستمی و التهاب عروقی سرم با آلبومینوری رابطهی مثبت دارند. بنابراین، مطالعهی حاضر به منظور بررسی اثرات تجویز توأم اسید لیپوئیک و پیریدوکسین روی غلظت سرمی این فاکتورها در بیماران مبتلا به نفروپاتی دیابتی صورت گرفت. مواد و روشها: این مطالعه یک کارآزمایی بالینی تصادفی دو ...
The purpose of this study was to investigate whether the expression of cellular adhesion molecules (CAMs) is enhanced in individuals with low HDL cholesterol (HDL-C). Plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), and E-selectin (sE-selectin) were measured in subjects with low (below the 10th percentile for the Italian populati...
An increasing death rate due to cardiovascular disease in patients with rheumatoid arthritis (RA) has been reported. Keishibukuryogan (KBG) is a traditional Chinese/Japanese (Kampo) formula that has been administered to patients with blood stagnation, e.g. thrombotic disease and atherosclerosis. The objective of this study was to evaluate the efficacy of KBG on disease activity and endothelial ...
BACKGROUND The phosphodiesterase inhibitor cilostazol has beneficial effects on atherosclerosis by virtue of vasodilatory and antiplatelet effects. However, less is known about the effect of cilostazol on arterial stiffness and biochemical markers related to vascular inflammation and endothelial dysfunction in type 2 diabetic patients with metabolic syndrome. METHODS In this randomized, doubl...
BACKGROUND The objective of this study was to evaluate the effects of green tea ingestion over four weeks on atherosclerotic biological markers. METHODS After a one-week baseline period, 12 healthy male volunteers aged 28--42 years drank 600 mL of green tea daily for four weeks. Lipid profile, oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), C-reactive protein (CRP...
OBJECTIVE This paper aims to investigate the interaction mechanism between pioglitazone/simvastatin and the CD40-CD40 ligand (CD40-CD40L) system and to determine their interaction effects on atherosclerosis in rabbits. MATERIALS AND METHODS Forty rabbits were randomly divided into five groups of eight: normal control, hyperlipidemia model, pioglitazone, simvastatin, and pioglitazone combined ...
OBJECTIVE A large-scale, prospective, randomized clinical trial has recently revealed that the addition of highly purified eicosapentaenoic acid (EPA) to low-dose statin therapy significantly reduces the incidence of major coronary events. Here we investigated in vivo and in vitro effect of EPA on monocyte adhesion to endothelial cells and adhesion molecules. METHODS AND RESULTS A new en face...
Background: Although hypertriglyceridemic waist (HW) phenotype has received much attention over recent years for its association with other metabolic abnormalities, it remains unknown whether its effects are mediated through changes in plasma concentrations of inflammatory markers. We aimed to evaluate the association between hypertriglyceridemic waist (HW) phenotype and markers of systemic inf...
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