Methods Seventeen healthy normal volunteers with Framingham score less than 1% underwent vasodilator stress testing with regadenoson using a SSFP sequence. Rest imaging (Rest 1) was performed initially. Twenty minutes later, regadenoson 400mcg was administered as a 10 second injection with saline flush. Stress imaging was done 70 seconds after the injection. All volunteers received aminophyllin...

Purpose: The aim of the present study was to investigate the diuretic activity of ethanolic extracts and its fractions of Aegle marmelos fruit in experimental models. Ethanolic extracts and its fractions of Aegle marmelos ripe fruit were administered to experimental rats intraperitonealy at doses of 300, 400 and 500 mg/kg i. p. Control group received only normal saline (25ml/kg) through intrape...

the effect of intracerebroventricular injections of prostaglandins e2 and f2a was studied on the rectal temperature of sheep. pge2 but not pgf2a at the same dose of 50mg elevated the 1h post-injection of rectal temperature. pge2 but not pgf2a at the same dose of 100mg increased 3.5 and 2h post-injection of rectal temperature, respectively. elavation of rectal temperature following pge2 and pgf2...

with the tremendous expansion in the use of herbal medicine worldwide, safety and efficacy as well as quality control of herbal medicine have become important concerns for both health authority and public. in this paper, the analysis of two st. john's wort (hypericum perforatum) products and four liquorice (glycyrrhiza glabra) products by spectrophotometric and hplc methods, is explained. moreo...

the plant chicorium intybus is used in traditional medicinal system as skin nourisher and to treat several skin aliments such as warts. the objective of this study was to evaluate ethanolic extract of chicorium intybus for its wound healing activity in rats. the extract was tested on three groups of male albino rats, consisting of six animals each, which were placed individually in cages. all a...

Abstract Introduction Testosterone deficiency (TD) is a prevalent condition, especially in men ≥ 45 years old, and testosterone therapy (TTh) can improve quality of life these patients. Objective In this abstract, we aim to evaluate the safety profile compounded subcutaneous pellets compare pharmacokinetics between FDA approved (Testopel®) for TTh. Methods This was prospective, Phase 3, randomi...

The effect of in vivo administration of disodium ethan-l-hydroxy-1.1-diphosphonate (EHDP) on the mitogenic response of thymocytes or spleen cells were studied in young rats. When rats (2-3 weeks of age) were injected with EHDP (10mg/kg/day) subcutaneously for more than 6 days or injected once with EHDP (100mg/kg) subcutaneously or intraperitoneally, lipopolysaccharide-induced proliferative resp...

Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforati...

Introduction: The larvicidal activity of oils, fatty acids, and methyl esters of Solanum lycocarpum fruit against Culex quinquefasciatus is unknown. Methods: The larvicidal activity of samples of ripe and unripe fruit from S. lycocarpum was evaluated against third and fourth instar larvae of C. quinquefasciatus. Results: The oils, fatty acids, and methyl esters of S. lycocarpum showed the great...