Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with M...

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We recorded unit activity in the auditory cortex (fields A1, A2, and PAF) of anesthetized cats while presenting paired clicks with variable locations and interstimulus delays (ISDs). In human listeners, such sounds elicit the precedence effect, in which localization of the lagging sound is impaired at ISDs less, similar10 ms. In the present study, neurons typically responded to the leading stim...

Leptospirosis is a worldwide deadly zoonotic disease. Accurate identification of the causative Leptospira spp. spirochetes ascertains the pathogenic status of the isolates, identifies potential source of infection and recognises outbreaks. Species identification is currently based on technically demanding, time and resources consuming serological and molecular methods. Matrix-assisted laser des...

AIM Patients with sustained ventricular tachyarrhythmias are at high risk for sudden cardiac death. The mechanisms leading to multiple temporally related episodes of ventricular fibrillation (VF) are not yet fully elucidated, and treatment options are limited. We investigated whether K(ATP)-channels could be involved in triggering VF. METHODS We determined postarrhythmic changes of monophasic...

Methods to correct the QT interval for heart rate are often in disagreement and may be further confounded by changes in autonomic state. This can be problematic when trying to distinguish the changes in QT interval by either drug-induced delayed repolarization or from autonomic-mediated physiological responses. Assessment of the canine dynamic QT-RR interval relationship was visualized by novel...

multiple sclerosis (ms) is an inflammatory demyelinating disease which the exact etiology is still are far to be clear. reasons for this autoimmune disease are unknown origin. the aim of present study was to evaluate serum levels of selenium in patient with ms compare to healthy subjects. a total of 46 subjects were enrolled in the study, sera of 23 ms cases and 23 healthy normal cohorts as con...

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ERECTOR SPINAE REFLEX STUDIES IN HEALTHY SUBJECTS REVEALED TWO RESPONSES: a 12·0±1·6 ms latency, oligosynaptic response, and a 30 to 50 ms latency response with polysynaptic reflex characteristics. There was a silent period after the first and second responses. The effect of limb position, trunk, neck, postural changes, Jendrassik manoeuvre and vibration on both responses were also evaluated.