Background: Increasing evidence from recent studies has revealed the association of CA125 with the diagnosis of pancreatic cancer, but inconsistent findings have been reported. We aimed to evaluate the diagnostic value of a serum CA125-based diagnostic panel in predicting malignant pancreatic cancer. Materials and Methods: We searched EMBASE, MEDLINE and Web of Science for relevant articles fro...

OBJECTIVES The present study investigated the clinical implications of pretreatment carbohydrate antigen 125 (CA-125) levels and CA-125 normalization in patients with ovarian clear cell carcinoma (CCC), and it provides useful information for the improvement of monitoring strategies for this lethal disease. METHODS The medical records of patients with ovarian CCC who had undergone primary stag...

BACKGROUND Automated and convenient multianalyte detection with high throughput is increasingly needed in clinical diagnosis. We developed a disposable 4-by-2 array for programmed simultaneous amperometric immunoassay of 4 tumor markers. METHODS We used a screen-printed technique, 1-step immobilization method, and flow injection technique. We immobilized carcinoembryonic antigen, alpha-fetopr...

The relentless discovery of cancer biomarkers demands improved methods for their detection. In this work, we developed protein imprinted polymer on three-dimensional gold nanoelectrode ensemble (GNEE) to detect epithelial ovarian cancer antigen-125 (CA 125), a protein biomarker associated with ovarian cancer. CA 125 is the standard tumor marker used to follow women during or after treatment for...

SUMMARY Infertility has a special importance in gynecology in causing social, psychological and somatic prohlems. Endometriosis is a benign but progressive disorder in reproductive life and is more common in infertile women. CA 125 is a cell membrane glycoprotein. The endometrium is one the known source of this antigen and seems to be elevated in the pelvic endometriosis. In this study, from...

Western blotting was performed to analyze Neospora caninum tachyzoite antigens recognized by mouse IgG at different stages of infection including recrudescence. At the early stage of infection, a 36-38 kDa antigen was clearly recognized by the mouse antisera. After day 48 postinoculation, the signal of the 36-38 kDa antigen gradually weakened. Meanwhile, a 43 kDa antigen was intensely and conti...

BACKGROUND Iodine interstitial brachytherapy has been widely reported for treating colorectal cancer (CRC). However, the inhibitory molecular mechanism of iodine-125 (I-125) on CRC has not been reported. METHODS To illustrate the inhibitory mechanism of iodine-125 (I-125) on CRC, we established the animal models of CRC via the injection of HCT-8 cells into nude mice. Subsequently, the I-125 g...

OBJECTIVE Plasma cancer antigen (CA)-125 is a tumour marker recently shown to be associated with systolic heart failure and new-onset atrial fibrillation (AF) after myocardial infarction. However, no reports have described the relationship between CA-125 and new-onset AF in healthy postmenopausal women. The aim of the present study was to evaluate the relationship between CA-125 and new-onset A...

We attempt to study the efficacy and adverse reactions of carboplatin, nab-paclitaxel regimen combined with atezolizumab in non-small cell lung cancer treatment. randomly selected 120 patients who received therapy our hospital from January 2019 December 2021 divided them into two groups, 60 cases respectively. Treated control group carboplatin paclitaxel pembrolizumab, while observation albumin...

Objectives: To determine the pattern of histological findings in prostatic chips obtained from cases enlarged prostate gland and to correlate with PSA levels. Materials Methods: It was a cross sectional descriptive study conducted Northwest General Hospital , Peshawar 1st January 2018 23rd December 2021. A total 500 male features prostate, frequency, urgency dribbling mean age 52 ± 12.3 years (...