Rabbit transferrin in vitro is shown to load ferrous iron at random on its specific binding sites. The release of iron to reticulocytes is shown to be an all-or-none phenomenon. The two monoferric transferrins have similar in vivo plasma iron clearance rates and tissue distribution. Diferric transferrin, while giving a similar tissue distribution of radioiron, has a plasma iron clearance rate a...

STUDY OBJECTIVES To evaluate the effects of single doses of gabapentin 250 and 500 mg on polysomnographic (PSG) and participant-reported sleep measures in a 5-h phase advance insomnia model. METHODS Adults reporting occasional disturbed sleep received gabapentin 500 mg (n = 125), 250 mg (n = 125), or placebo (n = 127) 30 min prior to bedtime and were in bed from 17:00 to 01:00, ∼5 h before th...

The 125 kW CW klystrons to be described in the first part of this paper were specifically designed for energy upgrading of the electron-positron storage ring, SPEAR II, at SLAC. Four tubes are required with an efficiency greater than 50 percent. The operating frequency is 358.54 MHz. The gain is approximately 50 dB, the operating voltage is 41 kV and the microperveance is 0.7. The klystron must...

We determined the effect of varying ventilator tidal volume (VT) and inspiratory flow (V) on the inspiratory muscle work (WI) during assist-mode mechanical ventilation (AMV) in four healthy subjects. In another four subjects, under constant chemoreceptor input, we determined the responses of neuromuscular output as assessed by the mouth occlusion pressure (P0.1) to alteration in WI. During AMV,...

The five largest US commercial health insurance companies together enroll 125 million members, or 43 percent of the country's insured population. Over the past decade these insurers have become increasingly dependent for growth and profitability on public programs, according to an analysis of corporate reports. In 2016 Medicare and Medicaid accounted for nearly 60 percent of the companies' heal...

Wind energy, if improperly sited, can impact wildlife through direct mortality and habitat loss and fragmentation, in contrast to its environmental benefits in the areas of greenhouse gas, air quality, and water quality. Fortunately, risks to wildlife from wind energy may be alleviated through proper siting and mitigation offsets. Here we identify areas in Kansas where wind development is incom...