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The (2;5)(p23;q35) translocation which results in the fusion of the NPM (nucleophosmin) gene on chromosome 5q35 with the novel ALK (anaplastic lymphoma kinase) gene on chromosome 2p23 [S.W. Morris et al., Science (Washington DC), 263: 1281-1284, 1994] is associated with Ki-1 (CD30)-positive anaplastic large cell lymphomas (ALCL); a group of morphologically and immunophenotypically heterogenous ...
The (2;5)(p23;q35) translocation which results in the fusion ofthe NPM (nucleophosmin) gene on chromosome 5q35 with the novelALK (anaplas tic lymphoma kinase) gene on chromosome 2p23 [S.W. Morris et aI, Science (Washington DC), 263: 1281-1284, 1994] is associated with lU-i (CD3O)-posltlve anaplastic large cell lymphomas (ALCL); a group of morphologicaHy and Immunophenotypically heterogenous hig...
OBJECTIVES We examined the effectiveness of risk reduction counseling and the role of on-site HIV testing in drug treatment. METHODS Between January and May 2009, we randomized 1281 HIV-negative (or status unknown) adults who reported no past-year HIV testing to (1) referral for off-site HIV testing, (2) HIV risk-reduction counseling with on-site rapid HIV testing, or (3) verbal information a...
Calcium transients are known to control several transition points in the eukaryotic cell cycle. For example, we have previously shown that a coordinate elevation in the intracellular free calcium ion concentration is required for G1to S-phase cell cycle progression in vascular smooth muscle cells (VSMC). However, the molecular basis for this Ca sensitivity was not known. Using buffers with diff...
The anti-diabetic drug metformin is endowed with anti-cancer properties. Epidemiological and experimental studies, however, did not provide univocal results regarding its role in pulmonary carcinogenesis. We used Swiss H mice of both genders in order to detect early molecular alterations and tumors induced by mainstream cigarette smoke. Based on a subchronic toxicity study, oral metformin was u...
Separate pathways have recently been proposed for ‘‘fast’’ and ‘‘slow’’ motion, whose properties differ in the way that color contrast is processed [see Nature (London) 367, 268 (1994); Trends Neurosci. 19, 394 (1966); and Vision Res. 36, 1281 (1996) and 35, 1547 (1995)]. One reported difference is that for slow motion the direction of chromatic stimuli cannot be determined at detection thresho...
We review the class of partial-propensity exact stochastic simulation algorithms (SSA) for chemical reaction networks. We show which modules partial-propensity SSAs are composed of and how partial-propensity variants of known SSAs can be constructed by adjusting the sampling strategy used. We demonstrate this on the example of two instances, namely the partial-propensity variant of Gillespie’s ...
The DMA content of murine fibrosarcoma cell lines of various metastatic potential was the subject of the current investigation. The cell lines were derived from methylcholanthrene-induced tumors as described previously (J. Varani ef al., J. Nati. Cancer Inst., 71: 1281-1287,1983). Cells were maintained in vitro and used for DNA studies no more than 48 h after passage. DNA staining was accomplis...
BACKGROUND Although the peroxisome proliferator-activated receptor-γ2 (PPARG2) Pro12Ala gene variant is associated with diabetes mellitus, the associations and interactions of this polymorphism and known clinical risk factors with glycated hemoglobin (HbA1c) remain poorly understood. We investigated if carrying the Ala allele was inversely associated with HbA1c level and examined possible inter...
Evaluation of: Valle J, Wasan H, Palmer DH et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362, 1273-1281 (2010). Biliary tract cancer is a rare disease and it is associated with a poor clinical outcome and survival. A standard therapy has not been established yet. The evaluated article reports on the first Phase III randomized controlled multicen...
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