BACKGROUND Structural valve deterioration (SVD) is a major flaw of bioprostheses. Early SVD has been suspected in the last models of Mitroflow bioprosthesis. We sought to assess the incidence, mode, and impact of SVD on outcome in a large series of Mitroflow aortic valve replacement. METHODS AND RESULTS Six hundred seventeen consecutive patients (aged 76.1±6.3 years) underwent aortic valve re...

PURPOSE We hypothesized that deregulated corepressor actions, with associated histone deacetylation activity, epigenetically suppressed vitamin D receptor (VDR) responsiveness and drives resistance towards 1alpha,25-dihydroxyvitamin D(3). EXPERIMENTAL DESIGN Profiling, transcriptional, and proliferation assays were undertaken in 1alpha,25(OH)(2)D(3)-sensitive MCF-12A nonmalignant breast epith...

A group of N-malonyl-1,2-dihydroisoquinoline derivatives were synthesized and investigated as brain specific and shelf-stable MAO inhibitors. N-malonyl-1,2-dihydroisoquinoline redox carrier system was linked through amidic bond to 4-chloro and 4-nitrobenzylidenehydrazines (9a-b), as monoamine oxidase inhibitors (MAOIs), and β-phenethylamine (14), as a model drug, to afford a novel group of N-ma...

In a previous study we found that liver mitochondrial side-chain hydroxylation of vitamin D3 (cholecalciferol) and of 5,8-cholestane-3a,7a,12a-triol was higher in female than in male rats [Saarem & Pedersen (1987) Biochem. J. 247, 73-78]. The present paper describes the effects of age, gonadectomy and hypophysectomy on these activites. The sex difference became manifest above the age of 7 weeks...

Structural motifs found in naturally occurring compounds are frequently used by researchers to develop novel synthetic drug candidates. Some of these new agents are hybrid molecules which are designed through a concept of combining more than one functional element. In this report, anticancer activity of new synthetic molecular hybrids, substituted 3-diethoxyphosphorylnaphtho[2,3-b]furan-4,9-dio...

BACKGROUND The risk factors for No. 12p and No. 12b lymph node (LN) metastases in advanced gastric cancer (GC) remain controversial. The aim of this study was to investigate the risk factors for No. 12p and No. 12b LN metastases in advanced GC. METHODS From January 1999 to December 2005, a retrospective analysis of 163 patients with advanced GC who underwent D2 lymphadenectomy in addition to ...

The Compressed Baryonic Matter experiment (CBM) at FAIR aims to study the area of QCD phase diagram high net baryon densities and moderate temperatures with collisions heavy ions sNN=2.8–4.9 GeV. anisotropic transverse flow is one most important observable phenomena in a properties matter created such collisions. Flow measurements require knowledge collision symmetry plane, which can be determi...

Karyotypes and chromosomal characteristics of both minor and major rDNAs in four fish species known popularly as "lambaris", namely Astyanaxabramis (Jenyns, 1842), Astyanaxasuncionensis Géry, 1972, Astyanaxcorrentinus (Holmberg, 1891) and Astyanax sp. collected from downstream of the Iguassu Falls (Middle Paraná River basin), preservation area of the Iguassu National Park, were analyzed by conv...

Citation Huang, F.-T. et al. " X-ray and electron diffraction studies of superlattices and long-range three-dimensional Na ordering in gamma-Na[subscript x] CoO[subscript 2] (x=0.71 and 0.84). Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article ope...

It is known that 1) elevated serum bile acids (BAs) are associated with decreased body weight, 2) elevated glucagon-like peptide-1 (GLP-1) levels can decrease bodyweight, and 3) germ-free (GF)mice are resistant to diet-induced obesity. The purpose of this study was to test the hypothesis that a lack of intestinal microbiota results in more BAs in the body, resulting in increased BA-mediated tra...