Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent conclusions from in vivo versus in vitro approaches. We have re-examined this question, both in vivo and in vitro, using apobec-1-/- mice to model the pattern of human hepatic apoB-100 secretion. Hepatic triglyceride productio...

Benzothiophene carboxamide derivatives of aminobenzophenone, aminopyridine, aminobenzimidazole, and aniline derivatives (compounds 1-9) were synthesized and compounds 3, 6, 7, 8, and 9 tested in vivo for their hypolipidemic activity. Compounds 1-8 were prepared adopting the fusion process at 130-150 degrees C between benzothiophene-2-carbonyl chloride and aminobenzophenones, aminopyridine, and ...

Triglyceride (TG), a water-insoluble energy-rich lipid, is secreted by the liver as part of very low density lipoproteins (VLDLs) to supply energy to extrahepatic tissues. Overproduction of VLDL is associated with increased risk of cardiovascular heart disease; this has renewed an interest in factors that affect hepatic TG production. The TG production rate is determined by measuring temporal i...

Serum myoglobin (by radioimmunoassay) and creatine kinase were measured for up to 7 days in 30 patients following surgical procedures, including total hip replacement and bilateral subcostal abdominal incisions. Serum myoglobin reached a maximum of 1390 micrograms litre-1 (median 345 micrograms litre-1 for major surgery patients) on the first postoperative day but levels were still elevated by ...

www.thelancet.com/infection Vol 15 February 2015 135 2 Peck FB Jr, Kohlstaedt KC. Pre-exposure rabies prophylaxis problems and procedures. Ind Med Surg 1964; 33: 17–21. 3 Doedee AM, Boland GJ, Pennings JL, et al. Eff ects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials. PloS One 2014;...

The turnover of rat liver lysosomal proteins was studied by a double isotope-labeling technique. The cellular fractions investigated included soluble lysosomal proteins, lysosomal membrane proteins, highly purified lysosomal beta-glucuronidase, and for comparison, microsomal proteins and soluble cytoplasmic proteins. Both "normal" lysosomes and Triton WR-1339-filled lysosomes (tritosomes) were ...

A community health survey was conducted to describe the current health status and preventive health practices of National Guard military employees and their dependants residing in the Eastern region of Saudi Arabia. In a cross-sectional survey in 2010, data were collected via a questionnaire interview and direct physical measurements. A total of 1339 adults aged 14 years completed the survey [m...

Synchronization of coupled fiber lasers has been reported in recent experiments [Bruesselbach, Opt. Lett. 30, 1339 (2005); Minden, Proc. SPIE 5335, 89 (2004)]. While these results may lead to dramatic advances in laser technology, the mechanism by which these lasers synchronize is not understood. We analyze a recently proposed [Rogers, IEEE J. Quantum Electron. 41, 767 (2005)] iterated map mode...

The density-distribution patterns of various enzymes and of labeled materials have been determined by isopycnic centrifugation in a sucrose-0.2 M KCl gradient on homogenates of lymphoid tissues from rats injected with Triton WR-1339, (14)C-labeled dextran, (51)Cr-labeled erythrocytes, and cortisol. The results confirm and extend the conclusion, derived from previous investigations on normal ani...