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Basal-like breast cancers frequently express aberrant DNA hypermethylation associated with concurrent silencing of specific genes secondary to DNMT3b overexpression and DNMT hyperactivity. DNMT3b is known to be post-transcriptionally regulated by microRNAs. The objective of the current study was to determine the role of microRNA dysregulation in the molecular mechanism governing DNMT3b overexpr...
Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respective...
The study of the epigenetic regulation of drug-metabolizing enzymes that might affect drug response and adverse drug reactions is important for understanding individual differences in drug response, drug metabolism and pharmacokinetics. Epigenetic modifications include transcriptional (DNA methylation and histone modification) and post-transcriptional (microRNA (miRNA) and ubiquitination) regul...
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