In our previous in vivo study we demonstrated that young BALB/c mice effectively rejected the BM-185 tumor cells expressing enhanced GFP (EGFP) as a surrogate tumor Ag. In contrast, old BALB/c mice succumbed to the BM-185-EGFP tumors, indicating that there is a deficiency in old animals preventing the rejection of immunogenic tumors. There is cumulative evidence indicating that regulatory T (T(...

AMA Szeliga J, Moszura T, Wójcik E, Mroczek Góreczny S. Percutaneous pulmonary valve implantation in a failed novel biorestorative valved conduit. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2023;19(2):182-185. doi:10.5114/aic.2023.129218. APA Szeliga, J., Moszura, T., Wójcik, E., Mroczek, & Góreczny, (2023). Interwencyjnej, 19(2), 182-185. https://doi.org/10.5114/a...

Ling, S., Mahon, I., Marzloff, M., Pizarro, O., Johnson, C., Williams, S. (2016). Stereo-imaging AUV detects trends in sea urchin abundance on deep overgrazed reefs. Limnology and Oceanography: Methods, 14(5), 293-304. [More Information] Bryson, M., Johnson-Roberson, M., Pizarro, O., Williams, S. (2016). True color correction of autonomous unde...

A field experiment was conducted on experimental farm of Dept. Agricultural Meteorology, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani, Maharasthra, India during the kharif season 2015 under rainfed condition to find relationship pheno thermal and heat use efficiency indices with yield. The laid out in factorial randomized bock design five sowing dates (i.e. 25th, 26th, 27th, 28th 29th ...

Psoriasis and atopic dermatitis (AD) are two of the most prevalent chronic inflammatory skin diseases in world. Currently, diagnosis psoriasis AD is conferred based on combination a visual exam review medical history. In some instances, overlapping clinical characteristics disease manifestations make it difficult to distinguish between AD, so biopsy collected for pathological analysis. While ef...

MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. Aberrant lipid and cholesterol metabolism is involved in prostate cancer development and progression to end-stage disease. We recently demonstrated that a key transcription factor for lipogenesis, sterol regulatory element-binding protein-1 (SREBP-1), induced fatty ...

Narcolepsy-cataplexy is a debilitating disorder of sleep/wakefulness caused by a loss of orexin-producing neurons in the lateroposterior hypothalamus. Genetic or pharmacologic orexin replacement ameliorates symptoms in mouse models of narcolepsy-cataplexy. We have recently discovered a potent, nonpeptide OX2R-selective agonist, YNT-185. This study validates the pharmacological activity of this ...

BACKGROUND The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate the interactions of cells with the extracellular matrix (ECM) and promote tumorigenesis in several malignancies. However, the role of ITGB5 in hepatocellular carcinoma (HCC) is still unknown. METHODS The biological functio...

Adeno-associated virus (AAV) integrates site specifically into the AAVS1 locus on human chromosome 19. Although recruitment of the AAV nonstructural protein Rep78/68 to the Rep binding site (RBS) on AAVS1 is thought to be an essential step, the mechanism of the site-specific integration, particularly, how the site of integration is determined, remains largely unknown. Here we describe the ident...

The M line, which transverses the center of the thick filament region of skeletal muscle sarcomeres, appears to be a complex array of multiple structural elements. To date, two proteins have definitely been shown to be associated with the M line. They are MM-CK, localized in the M 4,4' substriations, and a 165,000-dalton (164 kd) protein, referred to as both M-protein and myomesin. Here we repo...