We have previously shown that the regulation by interleukin-1b (IL-1b) of inducible nitric oxide synthase (iNOS) involves phospholipase A2 (PLA2) metabolites in neonatal ventricular myocytes. Based on studies in which ONO-RS-082 is used to inhibit secretory PLA2 and methyl arachidonyl fluorophosphonate is used to inhibit cytosolic PLA2, our data suggest that a secretory PLA2 metabolite was invo...

Recently, cell-based replicon systems for hepatitis C virus (HCV), in which the nonstructural proteins stably replicate subgenomic viral RNA in Huh7 cells, were developed. To date, one limitation of using these replicon systems to advance drug discovery is the inability of other genotypic derivatives, beyond those of two distinct strains of genotype 1b (HCV-N and Con1), to stably replicate in H...

background: interferon beta-la and -1b have been increasingly used for the treatment of multiple sclerosis (ms). the most frequent systemic adverse effects are flu-like symptoms. laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. myelodysplastic syndrome (mds) refers to a spectrum of hematological disorders which can occur in different situations. sever...

Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was c...

We report on our F-statistic search for white-dwarf binary signals in the Mock LISA Data Challenge 1B (MLDC1B) . We focus in particular on the improvements in our search pipeline since MLDC1, namely refinements in the search pipeline and the use of a more accurate detector response (rigid adiabatic approximation). The search method employs a hierarchical template-grid based exploration of the p...

MIPAS Level 1B algorithms overview: operational processing and characterization A. Kleinert, G. Aubertin, G. Perron, M. Birk, G. Wagner, F. Hase, H. Nett, and R. Poulin ABB Bomem Inc., 585 Blvd. Charest East, Québec, G1K 9H4, Canada Forschungszentrum Karlsruhe GmbH, Institut für Meteorologie und Klimaforschung, P.O. Box 3640, 76021 Karlsruhe, Germany Remote Sensing Technology Institute, German ...

Considerable evidence supports a role for brainstem adrenergic and noradrenergic inputs to corticotropin-releasing hormone (CRH) cells of the hypothalamic paraventricular nucleus (PVN), in the control of hypothalamic-pituitary-adrenocortical (HPA) axis function. However, little is known about specific adrenoceptor (ADR) subtypes in CRH-containing cells of the PVN. Here we demonstrate, using dua...

Gourine, Alexander V., Karin Rudolph, Johannes Tesfaigzi, and Matthew J. Kluger. Role of hypothalamic interleukin-1b in fever induced by cecal ligation and puncture in rats. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44): R754–R761, 1998.—Bacterial endotoxin induces fever by causing the release of interleukin (IL)-1b into the circulation or the brain. IL-1b is believed to mediat...

abstract: genotyping of the hepatitis c virus (hcv) is important for designing therapeutic strategies and regional specific diagnostic assays. the aim of this study was to identify the hcv genotypes in hcv infected blood donors. this is the first report on hcv genotypes in blood donors in iran. in this cross-sectional study, 103 blood donors with hepatitis c were investigated for hcv genotypes....