In the mol-ecule of the title compound, C(20)H(16)Cl(2)N(2)O(2), the planar benzimidazole ring system is oriented with respect to the furan and dichloro-benzene rings at dihedral angles of 53.39 (6) and 31.04 (5)°, respectively. In the crystal structure, inter-molecular C-H⋯Cl hydrogen bonds link the mol-ecules into centrosymmetric R(2) (2)(8) dimers. These dimers are connected via a C-H⋯π cont...

The title compound, C18H13Br3N2S2, was obtained via the reaction of N-bromo-succinamide with 5,6-dimethyl-2-(thio-phen-2-yl)-1-[(thio-phen-2-yl)meth-yl]-1H-benzimidazole. The compound exhibits rotational disorder of the 5-bromo-thio-phen-2-yl substituent with a refined major:minor occupancy ratio of 0.876 (7):0.124 (7). The 5-bromo-thio-phen-2-yl mean plane is canted to the benzimidazole plane ...

A series of novel substituted benzimidazole (7a - n) derivatives were synthesized and characterized by 1H, 13C Nuclear Magnetic Resonance (NMR) spectra High Resolution Mass Spectrometry (HRMS). The substitution was done in position -1 -2 appropriate groups. These compounds are obtained N-alkylation reaction with thiomethyl-1H-benzimidazole intermediates (5a g). Design g) made condensation betwe...

In the title compound, [Co(NO(3))(C(9)H(11)N(3))(2)]Cl·3H(2)O, the Co(II) atom is coordinated by four N atoms from two chelating 2-(2-amino-eth-yl)-1H-benzimidazole ligands and two O atoms from one nitrate anion in a distorted octa-hedral coordination environment. In the crystal, N-H⋯Cl, N-H⋯O, O-H⋯Cl and O-H⋯O hydrogen bonds link the complex cations, chloride anions and solvent water mol-ecule...

Enantioseparation of amino acid analogues racemic β-amino alcohols has hitherto been thought impossible without prior derivatization. Method developers of chromatographic enantioseparation often face detection challenge due to low ultraviolet (UV) absorbance of these molecules. A new chiral derivatizing reagent, benzimidazole-(S)-naproxen amide, was synthesized to provide UV detectable chiral m...

In the title compound, C(13)H(10)N(2)S, the dihedral angle between the imidazole and thio-phene rings is 16.89 (19)°, and the double bond adopts an E configuration. In the crystal structure, N-H⋯N hydrogen bonds link the mol-ecules into rows along b. There is also evidence of weak C-H⋯S inter-actions.

BACKGROUND The soil-transmitted helminths (STH) Ascaris lumbricoides and Trichuris trichiura are gastrointestinal parasites causing many disabilities to humans, particularly children. The benzimidazole (BZ) drugs, albendazole (ALB) and mebendazole (MBZ), are commonly used for mass treatment for STH. Unfortunately, there is concern that increased use of anthelmintics could select for resistant p...