A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic β-ketophosphonates that on reduction with sodium borohydride gave the required indolones in goo...

In the title compound {systematic name: N-[(4R,5R)-3,11-dioxo-10-oxa-6-thia-2-aza-tricyclo-[6.3.0.0(2,5)]undec-1(8)-en-4-yl]-2-phenyl-acetamide}, C(16)H(14)N(2)O(4)S, the four- and five-membered rings adopt planar conformations (with r.m.s. deviations of 0.0349 and 0.0108 Å respectively) while the six-membered ring adopts a half-chair, or envelope-like, conformation with the S atom in the flap ...

Saccharin Chem. Abstr. Serv. Reg. No.: 81-07-2 Deleted CAS Reg. Nos: 474-91-9; 61255-27-4; 126987-83-5 Chem. Abstr. Name: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide IUPAC Systematic Name: 1,2-Benzisothiazolin-3-one, 1,1-dioxide Synonyms: Acid saccharin; anhydro-ortho-sulfaminebenzoic acid; 3-benzisothiazolinone 1,1-dioxide; benzoic sulfimide; benzoic sulphinide; benzosulfimide; benzosulfinide; o...

Dexrazoxane (ICRF-187) is clinically used as a doxorubicin cardioprotective agent and to prevent anthracycline extravasation injury. It may act by preventing iron-based oxygen free radical damage through the iron-chelating ability of its metabolite N,N'-[(1S)-1-methyl-1,2-ethanediyl]bis[(N-(2-amino-2-oxoethyl)]glycine (ADR-925). Dexrazoxane undergoes an initial metabolism to its two one-ring op...