Many derivatives of 2,3-dimethoxy-4-hydroxypyridine, which were designed from examination of the structure-activity relationship of piericidins, were tested for inhibition of NADH-UQ reductase. The lipophilic side chain of those compounds was indicated to be a key part for activity and its optimal length was conjectured. By the use of two different phases of assay material, intact mitochondria ...

Cancer continues to have overwhelming impacts on human health and the development of new chemotherapeutics. Molecular hybridization has thus been valued as a structure-based drug design approach drugs with enhanced efficacy. Herein, we report multistep synthesis quinoline–2-mercapto-1,3,4-oxadiazole conjugates their cytotoxicity evaluation. Compound 4j 2-[(5-bromopentyl)thio]-5-[(quinolin-8-ylo...

5-Phenyl-furan-2-carboxylic acids have emerged as a new, promising class of antimycobacterial agents that the ability to interfere with iron homeostasis. Considering lack structural data on these compounds, we analyzed crystal fluorinated ester derivative 5-(4-nitrophenyl)furan-2-carboxylic acid, one most potent candidates in series. Here, describe preparation methyl 5-(2-fluoro-4-nitrophenyl)f...