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BACKGROUND EphA2 is a tyrosine kinase receptor that is overexpressed in many cancers and is associated with poor prognosis and increased metastasis. Phosphorylated Akt (pAkt) plays a role in the regulation of thyroid cancer invasion and metastasis. We investigated the role of EphA2 and Akt in FTC-133 and FTC-238, 2 closely related human cell lines with differing invasive phenotypes. METHODS W...
The radioactivity concentrations of 40 K, 238 U, 232 Th and 137 Cs in eighteen species of foodstuffs in the oil and gas producing areas in Delta State, Nigeria have been measured using a high purity germanium, (HPGe) detector system. The mean specific activities of 40 K, 238 U, 232 Th and 137 Cs vary between 36.48 – 68.02; 2.33 – 5.18; 1.26 – 2.98 and 0.27 – 2.47 Bq kg -1 respectively in vegeta...
PURPOSE To investigate the genetic basis and clinical manifestations of a characteristic form of retinal degeneration in the Yemenite Jewish population. METHODS Haplotype analysis for all known genes and loci underlying autosomal recessive nonsyndromic retinal degeneration was performed in a Yemenite Jewish family segregating autosomal recessive severe retinal degeneration. The causative muta...
INTRODUCTION The etiopathogenesis of basal cell carcinoma (BCC) is multifactorial. The TNF-α gene seems to be an interesting gene candidate for BCC susceptibility because of the proinflammatory and immunosuppressive properties of its product. The aim of the study was to assess the frequency of -308 G/A and -238 G/A gene polymorphisms in the TNF-α gene and serum levels of cytokine in patients wi...
Retinoic acid (RA) acts as an anti-proliferative and redifferentiation agent in the therapy of thyroid carcinoma. Our previous studies demonstrated that pretreatment of follicular thyroid carcinoma cell lines FTC-133 and FTC-238 resulted in decreased in vitro proliferation rates and reduced tumor cell growth of xenotransplants. In addition to the previous results, we found that RA led to decrea...
چکیده ندارد.
Purpose: Tumor necrosis factor-α (TNF-α) polymorphism has been suggested to play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) in obese adults, and known to be a mediator of insulin resistance. In this study, we evaluated the role of TNF-α promoter polymorphisms and insulin resistance in the development of NAFLD in obese children. Methods: A total of 111 obe...
Dwoskin et al. (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 238 days.
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