BACKGROUND Exposure of donor liver grafts to prolonged periods of warm ischemia before procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft loss. Due to unavoidable prolonged ischemic time before procurement in donation after cardiac death (DCD) donation in 1 participating center, each liver graft of this center was pretreated with the new machine perfusion...

Human constitutive androstane receptor (hCAR, NR1I3) is a member of the orphan nuclear receptor family and regulates the transcription of many drug-metabolizing enzymes and drug transporters. Previous studies have shown that the hCAR gene produces a number of different kinds of mRNA splicing variants (SVs) in non-Asian ethnicities. In the present study, we identified 18 hCAR SVs (SV1-SV18), inc...

Human constitutive androstane receptor (hCAR, NR1I3) is a member of the orphan nuclear receptor family and regulates the transcription of many drug-metabolizing enzymes and drug transporters. Previous studies have shown that the hCAR gene produces a number of different kinds of mRNA splicing variants (SVs) in nonAsian ethnicities. In the present study, we identified 18 hCAR SVs (SV1–SV18), incl...

Abstract Obesity is associated with increased deposition of fat in ectopic tissues, such as within the liver and visceral adipose depots, including omentum mesentery. Increased an accompanying feature metabolic syndrome end-organ damage NAFLD. Emerging evidence implicates intrahepatic B cells progression NAFLD, number proinflammatory have been found steatotic livers HFD-fed mice. Our preliminar...

Rossi X-ray Timing Explorer (RXTE) All Sky Monitor observations of the transient Be star X-ray source X0726−260 suggest a 34.5 day period. This is apparently confirmed by a serendipitous RXTE Proportional Counter Array (PCA) slew detection of the source on 1997 May 5, near the time of a predicted flux maximum. A subsequent 5ks pointed observation of X0726−260 with the RXTE PCA detector was carr...

This study evaluated the effects of calf management system following early-weaning (EW) on performance of beef steers. On d 0, Brahman x British steers (n = 40; bodyweight [BW] = 198 ± 26 lb; age = 72 ± 14 d) were stratified by age and BW, and randomly assigned to normal-weaning (NW; d 177) or 1 of 3 EW treatments: 1) EW and grazed on ryegrass pastures for 67 d then on bahiagrass pastures until...