BACKGROUND Ultraviolet-B (UVB) light sources are widely used for the safe and effective treatment of inflammatory skin conditions. The recent commercial introduction of fiber-coupled UVB phototherapy systems facilitates the selective exposure and treatment of localized psoriasis plaques while permitting the safe use of high-dosage treatments. OBJECTIVE In this study, the performance character...

Autofluorescence spectroscopy of arterial surfaces provides information about the distribution and composition of atherosclerotic plaques. The aim of the study was to determine whether accumulation of peroxidized lipoproteins in arterial walls, a process postulated to play a role in initiating atherosclerotic changes, can be demonstrated by fluorescence spectroscopy. XeCI excimer laser (308 nm)...

PURPOSE To ablate retina and vitreous membranes using the 193-nm argon fluoride excimer laser in a fluid medium. METHODS A special delivery system for the 193-nm excimer laser was developed that enabled the delivery of the laser into high-absorption liquid environments. The system was tested on the retina in an in vitro cup preparation of cow's eyes, and also in vivo on retina and vitreous me...

In this paper, we show the feasibility of the pulsed-laser ablation technique to grow 20–30-nm-thick, discrete and continuous coatings on particulate material systems so that the properties of the core particles can be suitably modified. Experiments were conducted with a pulsed excimer laser (l 4 248 nm, pulse duration 4 25 ns) to deposit nanoparticle coatings on Al2O3 and SiO2 core particles b...

PURPOSE The photobiology of purified recombinant crystallins has not been studied. Here we examine photo-induced aggregation of purified recombinant mouse betaA3-crystallin (rbetaA3) and compare it with that of betaL-crystallins isolated from bovine lenses. METHODS rbetaA3-Crystallin was expressed in baculovirus-infected Sf9 cells and purified by ion-exchange and gel-filtration chromatography...

In this communication, we show the feasibility of the pulsed laser ablation technique to make very thin, uniform luminescent coatings on particulate systems. To deposit continuous particulate coatings, the laser-induced plume from the target comes in contact with an agitated bed of core particles ~size 1 mm!. The pressure and nature of the background gas ~inert or active! controls the cluster s...

We use a novel technique, self-perfection by liquefaction (SPEL), to smooth the rough sidewalls of Si waveguides. An XeCl excimer laser with 308 nm wavelength and 20 ns pulse duration is used to selectively melt the surface layer of the waveguide. This molten layer flows under surface tension and this results in smooth sidewalls upon resolidification. Our experimental results show that this tec...

P-[2-(4-hydroxyphenyl)-2-oxo]ethyl ATP (pHP-caged ATP) has been investigated for its application as a phototrigger for the rapid activation of electrogenic ion pumps. The yield of ATP after irradiation with a XeCl excimer laser (l 5 308 nm) was determined at pH 6.0–7.5. For comparison, the photolytic yields of P-[1-(2-nitrophenyl)]ethyl ATP (NPE-caged ATP) and P-[1,2-diphenyl-2-oxo]ethyl ATP (d...

introduction: vitiligo is a cutaneous disorder of pigmentation, for which, there are some proven modalities of treatment. in this study, we evaluated the efficacy of the addition of topical pimecrolimus to 308nm excimer laser in reducing treatment duration and improving the response rate of eyelid vitiligo, compared with 308nm excimer laser monotherapy. methods: fifty two symmetrically localize...