The nucleotide sequence of T4 species I RNA, one of several stable RNA's specifically coded for by bacteriophage T4, has been determined using 32-P-labeled material from T4-infected cultures of Escherichia coli. The purified RNA species which has been sequenced has been shown to hybridize well to T4 DNA (Wilson J.H., Kim, J.S., and Abelson, J.N. (1972) J. Mol. Biol. 71, 547-556). The sequence i...

ANY observers have reported an increase in variability following exposure of pollen or seeds to the effect of ionizing radiation. In several respects the tomato is favorable material for such studies. I t is self-pollinating, and recessive mutants can therefore be uncovered promptly. It is a perennial and can be propagated by cuttings, so that plants of a previous generation can be retained, an...

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare autosomal inherited skin disorder caused by mutations in COL7A1 encoding type VII collagen (C7), the major component of anchoring fibrils. In this study, we report two cases RDEB patients with new pathogenic deep-intronic point COL7A1. Patient 1 45-year-old man inversa from unrelated healthy parents, for whom sequencing genomic DNA and...

Stagonospora nodorum blotch (SNB) caused by Parastagonospora is an important leaf spot disease in the mid-Atlantic United States. Disease management approaches include use of resistant varieties, cultural control, and foliar fungicides. Frequent fungicides can select for fungicide resistance within pathogen populations. Recently, first report quinone outside inhibitor (QoI) States was made base...

*KURAに登録されているコンテンツの利用については,著作権法に規定されている私的使用や引用などの範囲内で行ってください。 *著作権法に規定されている私的使用や引用などの範囲を超える利用を行う場合には,著作権者の許諾を得てください。ただし,著作権者 から著作権等管理事業者(学術著作権協会,日本著作出版権管理システムなど)に権利委託されているコンテンツの利用手続については ,各著作権等管理事業者に確認してください。 Title Colchicine-responsive chronic recurrent multifocal osteomyelitis with MEFV mutations: A variant of familial Mediterranean fever? Author(s) Shimizu, Masaki; Tone, Yumi; Toga, Akiko; Y...

OBJECTIVE To evaluate the expression of Von Hippel Lindau (VHL) gene in diagnosed cases of renal cell carcinoma. METHODS This cross sectional study was conducted in department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi, from January 2007 to December 2012. Paraffin embedded blocks of 30 cases of radical nephrectomy specimens diagnosed as renal cell carcinoma including CCRCC ...

BACKGROUND Tick-borne encephalitis virus (TBEV) infections may be asymptomatic or cause severe symptoms in the central nervous system. A mutation in the chemokine receptor 5 gene has been associated with increased risk of TBE but explains only a limited number of cases. Investigations of further risk factors are needed. METHOD To investigate the importance of the innate immune response, we an...

The need to characterize the genetic basis for phenotypes in Caenorhabditis elegans arises from its astonishingly high homology to humans and other eukaryotic organisms. In particular, aspects of the dpy genes’ structure and function, which encodes a flexible and resilient exoskeleton (i.e., cuticle collagen) crucial for normal body morphology in C. elegans, can be applied to other organisms. W...

To get clues about the genes as well as the gene regulatory circuit controlling the lytic development of temperate mycobacteriophage L1, previously we screened several conditional lethal mutants of L1 and characterized some of them to an extent. One of the mutants, L1 G23ts23, was found defective in both growth and late gene transcription at 42 degrees C but not at 32 degrees C. Here we show th...