AIMS To evaluate the number of lymph nodes and the lymph node tumour burden in different anatomical pelvic regions to better asses the impact of variations in the extent of lymphadenectomy on reported LN parameters and pelvic tumour clearance. METHODS 162 patients with lymph-node-positive urothelial carcinoma of the bladder were treated by cystectomy and extended pelvic lymphadenectomy. Vario...

Chronic kidney disease (CKD) is a major health care problem, affecting more than 35% of the elderly population worldwide. New interventions to slow or prevent disease progression are urgently needed. Beneficial effects of mesenchymal stem cells (MSC) have been described, however it is unclear whether the MSCs themselves or their secretome is required. We hypothesized that MSC-derived conditione...

OBJECTIVE To explore the usefulness of neck circumference as a supplemental tool for diagnosing metabolic syndrome while identifying its cut-off values. METHODS This case-control study was conducted at Dr. Essa's Laboratory and Diagnostic Centre, Karachi, from December 2014 to April 2015, and comprised subjects with and without metabolic syndrome aged between 35 and 65 years regardless of the...

C M P0 4 The arrowed objects are tyrosine crystals. Tyrosine crystals are rare and their presence in urine is always abnormal. They form clusters of silky needle-like structures that are colorless, or black on focusing. Tyrosine crystals are found in acid urine, increase after refrigeration, and are insoluble in alcohol or ether. They are soluble in dilute hydrochloric acid, alkali and relative...

We define two such pairs (X, i), (Y, j) to be equivalent if there is an isogeny α : X → Y such that if α̃ : End(X) ' End(Y ) is the induced isomorphism, we have α̃ ◦ i = j. It is easy to check that this is an equivalence relation. We write X ∼ Y if (X, i) is equivalent to (Y, j). Let AF be the collection of equivalence classes. We will classify such equivalence classes. Let D be any R-algebra. A ...

The system consists of more than 68,000 codes, compared to approximately 13,000 ICD-9-CM codes. ICD-10-CM codes have the potential to reveal more about quality of care, so that data can be used in a more meaningful way to better understand complications, better design clinically robust algorithms, and better track the outcomes of care. ICD-10-CM incorporates greater specificity and clinical det...

El cáncer de colon es una enfermedad frecuente que puede ser esporádica o familiar. La inactivación del gen supresor de tumores APC (adenomatous polyposis coli) se ha encontrado en más del 80% de los casos descritos de tumores colorrectales, apareciendo como una alteración temprana durante el desarrollo del pólipo adenomatoso. La inactivación del gen APC no es únicamente crítica en el proceso d...