nétics for prepackaged emergency contraceptive pills. The application was approved, and the company began marketing the product (under the trade name Preven) in September 1998. This development presumably indicates a more open and positive policy climate for emergency contraception, and the product should lead to standardization of postcoital contraception service delivery at the clinic level. ...

Kwon, Hyeok Y., Ta-Min Chang, Kae Y. Lee, and William Y. Chey. Vagus nerve modulates secretin binding sites in the rat forestomach. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1052–G1058, 1999.—Secretin is well known for its inhibitory action on gastric motility. It has been reported that secretin in a physiological dose inhibits gastric motility through mediation by the vagal affer...

Asfaha, Samuel, Cameron J. Bell, John L. Wallace, and Wallace K. MacNaughton. Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G703–G710, 1999.—Colonic epithelial secretion is an important host defense mechanism. We examined whether a bout of colitis would produce long-lasting changes i...

Leclercq-Meyer, Viviane, Marcel M. Kadiata, and Willy J. Malaisse. Stimulation by 2-deoxy-D-glucose tetraacetates of hormonal secretion from the perfused rat pancreas. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E689– E696, 1999.—The effects of aand b-2-deoxy-D-glucose tetraacetate (1.7 and 8.5 mM) on insulin, somatostatin, and glucagon secretion from isolated rat pancreases perfused in the pr...

Wiest, Reiner, Vijay Shah, William C. Sessa, and Roberto J. Groszmann. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1043–G1051, 1999.—Chronic high blood flow and the hyperdynamic circulatory syndrome in portal hypertension are associated with endothelial constitutive nitric oxide (NO) ...

Chisholm, Jeffrey W., Patrick Nation, Peter J. Dolphin, and Luis B. Agellon. High plasma cholesterol in drug-induced cholestasis is associated with enhanced hepatic cholesterol synthesis. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1165–G1173, 1999.—In a-naphthylisothiocyanate-treated mice, plasma phospholipid (PL) levels were elevated 10and 13-fold at 48 and 168 h, respectively, wh...

KChIPs coassemble with pore-forming Kv4 a subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K1 channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. The structure reveals a unique clamping action of the co...

Results: Mean age of the children in the obese group (n= 27) was 8.1 ± 2.6 while that in the non-obese group (n= 71) was 8.6 ± 2.9 (p= 0.41). Asthma symptom score in obese and non-obese groups were not significantly different (p= 0.73). Children in the obese group had lower ACQ scores when compared to the non-obese group (1.2 ± 0.9 vs 1.7 ± 1.0, p= 0.04) however this significance was lost when ...

J. M. ANDREWS,1 H. NATHAN,2 C. H. MALBERT,3 M. A. M. T. VERHAGEN,4 M. GABB,5 G. S. HEBBARD,1 D. KILPATRICK,6 S. MACDONALD,2 C. K. RAYNER,1 S. DORAN,1 T. OMARI,7 E. O’YOUNG,2 C. FRISBY,2 R. J. FRASER,1 M. SCHOEMAN,2 M. HOROWITZ,1 AND J. DENT2 Departments of 1Medicine, 2Gastrointestinal Medicine, and 5Radiology, Royal Adelaide Hospital, and 7Department of Gastroenterology, Women’s and Children’s ...

Simmons, James G., Jolanta B. Pucilowska, and P. Kay Lund. Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G817–G827, 1999.— Paracrine and autocrine actions of the insulin-like growth factors (IGFs) are inferred by local expression within the bowel. CCD-18Co cells, IEC-6 cells, and immunoneutral...