The aim of the present paper is to compare the integral dose received by non-tumor tissue (NTID) in stereotactic body radiation therapy (SBRT) with modified LINAC with that received by three-dimensional conformal radiotherapy (3D-CRT), estimating possible correlations between NTID and radiation-induced secondary malignancy risk. Eight patients with intrathoracic lesions were treated with SBRT, ...

Survival for patients with stage III non-small-cell lung cancer has gradually improved in recent years, with median survival times increasing from less than 10 months to more than 18 months. These increases are thought to result primarily from advances in chemoradiation. This article reviews major advances in the development of chemoradiation for patients with locally advanced non-small-cell lu...

Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by elimin...

Hypofractionated radiotherapy for prostate cancer has become of increasing interest with the recognition of a potential improvement in therapeutic outcome with treatments delivered in large-sized daily fractions. In addition, hypofractionation offers a reduction in fraction number and produces attractive cost and increased convenience for patients. There is convincing evidence, by several clini...

Due to acute and particularly chronic postirradiation complications in radiotherapy of the prostate, the dose application, and consequently also the irradiation effect, are restricted. The incidence and grade of acute and chronic complications depend upon the dose and volume of the surrounding organs involved in the irradiation area.1-4 As the restrictions on dose application should in no way b...

PURPOSE Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either 3D-CRT or IMRT and analyzed the prognostic factors for survival. METHODS Fr...

Objective: Intensity modulated radiotherapy (IMRT) is an exciting new technique with the potential to improve radiotherapy treatment by reducing dose to normal structures and increasing dose to the cancer. The objective was to investigate the potential value of IMRT in the treatment of sarcoma. To compare normal tissue sparing and treatment volume coverage for both three dimensional conformal (...

Objective: To investigate the feasibility of hippocampal-sparing whole-brain radiotherapy and reduction in neurocognitive function impairment after radiotherapy. Methods: Forty-three patients with brain metastases were selected. Whole-brain radiotherapy was performed in 22 patients, with 3-dimensional conformal radiotherapy in parallel opposed fields. Twenty-one patients had significant differe...

Introduction Polymer gel dosimeters offer a practical solution to 3D dose verification for conventional radiotherapy as well as intensity-modulated and stereotactic radiotherapy. In this study, EGSnrc calculated and PAGAT polymer gel dosimeter measured dose profiles from single shot irradiation with 18 mm collimator of Gamma Knife in homogeneous and inhomogeneous phantoms were compared with eac...