The syntheses of two new ligands, 3,4-di(2-pyridyl)-1,2,5-oxadiazole (dpo) and 3,4-di(2-pyridyl)-1,2,5-thiadiazole (dpt), are described. Complexes with palladium and copper have seven-membered chelate rings with coordination through the two pyridine nitrogens, whereas in the silver nitrate complex of dpt the ligand acts as a bridge between metal centres. Studies of the mononuclear ruthenium com...

The influence of a structural modification on thermodynamic aspects of solubility and hydration processes of 1,2,4-thiadiazole drug-like compounds was investigated. A substitution in the phenyl ring of the 1,2,4-thiadiazole molecule leads to a significant decrease of the solubility of these compounds. In order to rationalize the relationship between the structures of 1,2,4-thiadiazoles and thei...

Several compounds were administered to pregnant Wistar-derived rats either 24 or four hours prior to the recovery of day 10 embryos for in vitro culture in Waymouth's medium and fetal calf serum. The compounds tested were 2-amino-1,3,4-thiadiazole (thiadiazole), cadmium sulfate, 1,2-dibromo-2,2-dichloroethyl dimethyl phosphate (dibrom), 2-(sec-Butyl)-4,6-dinitrophenol (dinoseb), led nitrate, po...

That Thiadiazoles derivative is biologically active as antimicrobial agents in cooling fluids.
 Derivatives of 1, 3, 4- thiadiazole have prepared:
 
 2-amino-3-[(2-amino-1, 4-thiadiazol-5-yl) dithio] propanoic acid.
 2-(2-Carbethoxyamino-1, 4-thiadiazol-5-yl)-thio acetic [(5-amino-1,3,4-thiadiazol-2-yl) acid
 The synthesized compounds been used against the microorganism...