0 7 4 0 7 4 5 9 / 0 0 / $ 1 0 . 0 0 © 2 0 0 0 I E E E ground. We agree with F.G. Harold’s concept of “optimal heterophily”1 and use the term software engineering to include information technology. Y2K presented a formidable (albeit welldefined) challenge: find the date problems and fix them (see our “Congratulations” in the accompanying sidebar). Post-Y2K presents a more formidable challenge: a...

Mainstream Information Technology professionals have misunderstood the Pick environment for many years. The Pick environment has been conceived, designed and built with business solutions as its key driver. At its heyday there were over 3,000 business applications available across a very wide range of hardware platforms supporting from 1 to thousands of real time users. The tentative economic r...

Award Number: W81XWH-08-1-0108 TITLE: The role of eIF4E activity in breast cancer PRINCIPAL INVESTIGATOR: Thomas A Hughes CONTRACTING ORGANIZATION: University of Leeds Leeds LS2 9-0000 REPORT DATE: August 2010 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT:  Approved for public release; distribution ...

Fatigue is a recognised problem in the transport industry. It has been attributed to two main influences: time of day and the time since last sleep. While the role of these two influences in producing fatigue is not disputed, there is less agreement on how they interact with one another. The aim of this study was to examine the relative effects of time of day and sleep deprivation on fatigue an...

Prior studies have shown that the IT innovation capability, a company's ability to innovate systematically with IT, is not easily replicated (persistent), and the persistence tends to be more pronounced during periods when economy-wide IT budgets are declining (hard IT budgets), such the post-Y2K period. Building on resource based view we argue that companies that systematically innovate with I...

Award Number: W81XWH-08-1-0108 TITLE: The role of eIF4E activity in breast cancer PRINCIPAL INVESTIGATOR: Thomas A Hughes CONTRACTING ORGANIZATION: University of Leeds Leeds LS2 9-0000 REPORT DATE: August 2010 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT:  Approved for public release; distribution ...

We examine the state of game theory. Many important questions have been answered, and game theoretic methods are now central to much economic investigation. We suggest areas where further advances are important, and argue that models of learning and of social preferences provide promising routes for improving and widening game theory’s predictive power, while preserving the sucesses of existing...

This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this cross-sectional study at a tertiary center in São Paulo, Brazil, for further workup. A...

B acteremia refers to the presence of bacteria in the blood, which usually occurs when pathogens gain entrance to the blood stream through abscesses, infected wounds or burns or from areas of localized disease (1). In human immunodeficiency virus (HIV) infected children, bacterial infections are a major source of morbidity and mortality. The most common opportunistic infections in children in t...

BACKGROUND Mediterranean spotted fever (MSF) is an acute febrile, zoonotic disease caused by Rickettsia conorii and transmitted to humans by the brown dogtick Rhipicephalus sanguineus. Nearly four hundred cases are reported every year (mainly from June to September) on the Italian island of Sicily. The aim of the study was to analyze the clinical and laboratory characteristics of patients with ...