BACKGROUNDS Portal vein embolization (PVE) has been widely applied before extended hepatectomy; however, its clinical utility for patients with biliary cancer has not been fully addressed. METHODS Between 1991 and 2010, 494 patients with cholangiocarcinoma (n = 353) or gallbladder cancer (n = 141) underwent PVE before extended hepatectomy. PVE was performed by a transhepatic ipsilateral appro...

Several intracellular pathogens arrest the phagosome maturation in the host cells to avoid transport to lysosomes. In contrast, the Leishmania containing parasitophorous vacuole (PV) is shown to recruit lysosomal markers and thus Leishmania is postulated to be residing in the phagolysosomes in macrophages. Here, we report that Leishmania donovani specifically upregulates the expression of Rab5a...

Here, we sequenced the genome of the influenza A/Finland/741 M/2014(H1N1) virus and found that the virus accumulated oseltamivir resistance mutation H275Y in its neuraminidase during propagation in cell culture. This indicates that propagation in cell culture modifies virus genomes. The instability of influenza genomes should be taken into consideration during drug-sensitivity studies.

Pompe disease is an inherited, autosomal-recessive deficiency of acid alpha-glucosidase (GAA), a lysosomal enzyme required for the breakdown of glycogen [1]. The prevailing pathology is a generalized build-up of glycogen within lysosomes leading to profound skeletal and cardiac myopathy with the severity of symptoms being directly correlated with residual GAA activity [1]. In the most severe fo...

122]. Abstraction [132]. accelerated [741]. Accelerating [725]. Access [109, 52, 85, 130, 115, 147, 56, 208, 305, 587, 370, 617, 389, 368, 233, 169, 335]. accessing [200]. Accounting [188]. Accuracy [473]. accurate [231, 394]. achieving [304]. ACM [220]. ACME [666]. across [183]. Active [180, 108, 74, 698, 387].

Arkadiusz Jabłoński, Polski leksykon japońskich terminów gramatycznych, Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika w Toruniu, Toruń 2021, t. 1 (A–K, ss. 494), 2 (L–R, 406), 3 (S–Z, 394)

The solidification heat transfer, melt convection and volume shrinkage in the casting of an energetic material are analyzed through numerical modeling and experimental investigation. The shrinkage resulting from phase change is considered through the volume of fluid method. The model is validated against an analytical solution and then applied to study the volume contraction during the casting ...