Anaphylactic reaction to meloxicam has never been reported to date. We report 2 cases of meloxicam-induced anaphylactic reaction with no sensitivity to another selective cyclooxygenase 2 inhibitor. A thorough drug allergy work-up should be done before other cyclooxygenase inhibitors are prescribed.

Recently, we found that dexamethasone caused a depletion of CD25- CD4+ T cells, but it increased the number of CD25highCD4+ and CD25lowCD4+ T cells. We also determined meloxicam-induced increase in the number of CD25highCD4+ T cells. In view of this, and taking into consideration the latest reports indicating that meloxicam shows an anti-proliferative effect on bovine peripheral blood mononucle...

BACKGROUND Although clinical trial results suggest that meloxicam has less gastrointestinal toxicity than most other non-steroidal anti-inflammatory drugs (NSAIDs), in practice it has been associated with a large number of yellow card reports of gastrointestinal complications. AIMS To estimate whether meloxicam and the coxibs, rofecoxib and celecoxib, have been channelled towards high risk pa...

BACKGROUND Lines of evidence have indicated that cyclooxygenase 2 plays a role in the pathophysiology of neuropathic pain. However, the site and mechanism of its action are still unclear. Spinal glia has also been reported to mediate pathologic pain states. The authors evaluated the effect of continuous intrathecal or systemic cyclooxygenase-2 inhibitor on the development and maintenance of neu...

In the title compound, C(12)H(24)O(4), the dioxane ring adopts a chair conformation; the n-hexyl chain, which occupies an equatorial position, has an extended zigzag conformation. In the crystal, mol-ecules are connected by O-H⋯O hydrogen-bonds into a zigzag chain running along the b axis, giving rise to a herringbone pattern.

HIGHLIGHTS OF PRESCRIBING INFORMATION -----------------------WARNINGS AND PRECAUTIONS-----------------------­ These highlights do not include all the information needed to use MOBIC  Serious and potentially fatal cardiovascular (CV) thrombotic events, safely and effectively. See full prescribing information for MOBIC. myocardial infarction, and stroke. Patients with known CV disease/risk facto...

group. There were no significant differences in the 24-hr changes in GFR or serum cortisol level, This study showed that perioperative administration of meloxicam reduced unfayorable postoperative changes in the cardiovascular system without influencing renal function. KEy woRDs: canine, cardiovascular parameters, meloxicam, preemptive analgesia, telemetry system, J. vlet, Med, Sci. 69(9): 939-...

A simple and short HPLC-UV screening method for the determination of residues for seven NSAIDs (carprofen, diclofenac, flunixin, meloxicam, phenylbutazone, tolfenamic acid, vedaprofen) and their three metabolites (4-methylaminoantipyrine, 5-hydroxyflunixin, oxyphenbutazone) in cow’s milk has been developed. The sample preparation was based on liquid-liquid extraction with acetonitrile in the pr...

AIM To investigate the effect of the administration of a single dose of meloxicam pre-emptively on postoperative pain management in patients who underwent inguinal hernia repair under local anaesthesia. SUBJECTS AND METHOD Fifty patients who underwent inguinal hernia repair under local anaesthesia during the period November 2005 to May 2006 were recruited into the study prospectively. The pat...

BACKGROUND Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for ...