A new series of 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl -3-[(1-phenyl-5-substituted phenyl)-5-hydro-1H-pyrazol-3-yl-amino]-6,8-dibromoquinazolin-4(3H)-ones C1-13 have been synthesized by the reaction of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-substituted phenyl chromene amido-6,8-dibromo-quinazolin-4(3H)-ones with phenylhydrazine in the presence of glacial acetic acid. The chalcones ...

A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3(5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide to afford the desired N-aryl-C-nitroazoles in good yields. This synthetic route has also been successfully applied to obtain N-phenyl derivativ...

2-Aminodienes, in which the enamine function is incorporated in a five-, six-, or seven-membered ring, react with dimethyl acetylenedicarboxylate in a sequence of [2+2] cycloaddition and electrocyclic ring-opening to form the two-carbon ring expanded unsaturated heterocycles, i.e., 3,4dicarboxylate substituted 6,7-dihydro-1H-azepines 3, 8 and 21, 1,6,7,8-tetrahydroazocines 22, and 6,7,8,9-tetra...

A series of novel pyrazoline derivatives 5-(substituted aryl)-3-(3,4-dimethoxyphenyl)-1-(2,4dinitrophenyl)-4,5-dihydro-1H-pyrazole (5a-l) were synthesized by heating 2,4-dinitrophenyl hydrazine (4) with (E)-3-(3,4-dimethoxyphenyl)-1-substituted aryl prop-2-en-1-one (3) in presence of catalytic amount of concentrated H2SO4. The structures of the novel derivatives were confirmed by various spectr...

Ethyl-1H-benzotriazol-1-acetate 2 was prepared by reacting 1H-benzotriazole 1 in alcohol with ethyl bromoacetate in presence of anhydrous potassium carbonate, which was treated with hydrazine hydrate under reflux for 1824 hours to obtain the intermediate 1H-benzotriazole-1-acetic acid hydrazide 3. This compound on Schiff’s reaction with aromatic aldehydes in presence of solvent mixture yielded ...

The title compound, C23H25N3O4, {systematic name: 1-benzyl-4-[(3aR,5R,6R,6aR)-6-benz-yloxy-2,2-di-methyl-tetra-hydro-furo[2,3-d][1,3]dioxol-5-yl]-1H-1,2,3-triazole}, consists of a substituted 2,2-di-methyl-tetra-hydro-furo[2,3-d][1,3]dioxole. The furan-ose ring adopts an envelope conformation close to C 3-exo, where the C atom substituted by the benz-yloxy group is the flap. The fused dioxolane...

Intramolecular nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole esters is described. Efficient routes towards the synthesis of pyrrolopyrazinone, pyrrolotriazinone and pyrrolooxazinone have been developed. First, N-alkyne-substituted pyrrole ester derivatives were synthesized. Introduction of various substituents into the alkyne functionality was accomplished by a copp...

A series of N’, N’’-[1-(1H-benzimidazole-2-yl)-2-(4-substituted phenyl ethane-1, 2-diyl)] substituted aromatic amines (AK1AK6) and hydrazides (AKH6 – AKH11) were synthesized by treating 2-methyl benzimidazole with different substituted aromatic aldehydes in the presence of ethanol to produce 2-[2-(4 chlorophenyl)-vinyl]-1H-benzimidazole. It was brominated to 2-[1, 2 dibromo 2-(4-substituted phe...

A series of 5-sulphanyl derivatives of 1-Benzyl-2-alkyl-4-nitro-1H-imidazoles (5-9) were prepared by the coupling method of 3-(1-Benzyl-2-ethyl-4-nitro-1H-imidazole-5ylsulfanyl)propanoic acid (4) with appropriate amino acid ester hydrochloride, in the presence of hydroxybenzotriazole (HOBT) and DCC. Compounds (10-12) and (13) were similarly synthesized using appropriate amino alcohols, and 1-su...