Monoclonal antibodies (mAb) are being used at an increasing rate in the treatment of cancer, with current efforts focused on developing engineered antibodies that exhibit optimal biodistribution profiles for imaging and/or radioimmunotherapy. We recently developed the single-chain Fv-Fc (scFv-Fc) mAb, which consists of a single-chain antibody Fv fragment (light-chain and heavy-chain variable do...

Thyroid follicular adenomas (FA) are encapsulated tumors lacking vascular, capsular or lymphatic invasion and the typical nuclear features of papillary carcinoma (PC). However, some FA demonstrate nuclear atypia reminiscent of either follicular carcinomas (FC) or follicular variant of papillary carcinomas (FVPC), suggesting they may represent precursors of malignant transformation. We hypothesi...

Environmental factors, such as ambient temperature (T), feather cover (FC), and housing system (HS), probably affect energy requirements of laying hens. Using a 3 × 2 × 2 factorial arrangement, interaction effects of T (11, 16, and 21°C), FC (100 and 50%), and HS (cage and floor housing) on energy partitioning and performance of laying hens were investigated. Six batches of 70 H&N Brown Nick la...

background & aim: osmotic stress in plants lead to increase free radicals and plants use different mechanisms to scavenge these radicals. so, researchers apply stresses especially drought stress to increase secondary metabolites such as phenolics, and antioxidants. one of the valuable medicinal plants is yarrow (achillea tenuifolia) which is a perennial plant with different medicinal applic...

in this study the response of 9 rapeseed genotypes were evaluated at the seedling stage using different irrigation levels (50, 70 and 100% fc). a factorial experiment based on rcbd was conducted in the research greenhouses of urmia university with four replications during summer of 2013. some physiological traits such as relative water content, stomatal conductance, transpiration, photosynthesi...

BACKGROUND Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). OBJECTIVES To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. METHODS Male Sprague Dawley rats (140-260 g) were treated with either OPG-Fc (3 mg/kg, subcutaneously) or vehicle (phosphate...

The purpose of the present research was to study the comparative influence of lisinopril and losartan on the parameters of cardiac hemodynamics and kidney function state in CHF (Congestive Heart Failure) patients with NYHA Functional Class (FC) I-III. Methods: The study included 92 CHF patients aged from 41 to 75 years (mean age 66.3±9.8 yrs) with FC I-III of ischemic genesis. The patients were...

Background: Early diagnosis of cystic fibrosis (CF) and hence the initiation symptomatic prophylactic treatment can help improve outcomes CF patients. Fecal calprotectin (FC) is a marker inflammation in intestinal tract that elevated several gastrointestinal inflammatory diseases, but little known about its value CF. Objectives: This study, therefore, aimed to survey associations FC among patie...

Background & Aim: Osmotic stress in plants lead to increase free radicals and plants use different mechanisms to scavenge these radicals. So, researchers apply stresses especially drought stress to increase secondary metabolites such as phenolics, and antioxidants. One of the valuable medicinal plants is yarrow (Achillea tenuifolia) which is a perennial plant with different medicinal a...