BACKGROUND Alloimmunization against human platelet antigens (HPAs) during pregnancy is rare but can lead to severe bleeding disorders, such as fetal and neonatal alloimmune thrombocytopenia. STUDY DESIGN AND METHODS In a cohort of 241 uncomplicated pregnancies, we investigated the immunogenicity of HPA mismatches and correlated HLA sensitization with HPA antibody formation. HPA antibodies wer...

Increased expression and secretion of heparanase (Hpa) by tumor cells promotes tumor invasion through extracellular matrices, tissue destruction, angiogenesis, and metastasis. Here, we show the existence in breast cancer patients of Hpa-specific T lymphocytes by fluorescence-activated cell sorting flow cytometry using Hpa peptide-MHC class I tetramers. We furthermore show memory T-cell response...

Alveolar epithelial cells outnumber alveolar macrophages by ~500 fold and increasing evidence suggests Mycobacterium tuberculosis may replicate dramatically in these cells during the initial weeks of infecting the lung [1,2]. Here, we report in experimental detail the transcriptional profiling of Mycobacterium tuberculosis replicating at 72 hr post-infection in the human type II alveolar epithe...

Emergence and resurgence of mosquito-borne diseases such as malaria, dengue, Japanese encephalitis and filariasis both in tropical and subtropical regions are well known. It is estimated that 500 million – one in every ten persons suffer from one or more tropical diseases and the global situation of lymphatic filariasis is reported as the 4th rank1.. The geo-climatic conditions in India are con...

BACKGROUND AND OBJECTIVES The aim of the 15th ISBT Platelet Immunology Workshop was to evaluate the detection of free platelet-reactive autoantibodies from ITP patients by the use of a standardized MAIPA protocol, to compare sensitivity and specificity of antibody detection for anti-HPA-1a and serologically difficult-to-assess antibodies against HPA-3, to identify whether anti-HPA-1a titration ...

Based on the fifth-generation European Center for Medium-Range Weather Forecasts reanalysis data (ERA5), real-time observation from weather stations, and radar products in Guangdong Province, we analyze precipitation properties formation mechanisms of “5·31” extreme heavy rainfall process with record-breaking 3-h accumulated South China during 2021. The results show that is caused by joint acti...

Using the Goddard Laboratory for Atmospheres Goddard Earth Observing System 5-yr analyses and the Zwack–Okossi equation as the diagnostic tool, the horizontal distribution of the dynamic and thermodynamic forcing processes contributing to the maintenance of a Northern Hemisphere midlatitude blocking anticyclone that occurred during the summer season were examined. During the development of this...

Hypothalamus-pituitary-adrenal (HPA) hyperactivity is observed in many patients suffering from depression and the mechanism underling the dysfunction of HPA axis is not well understood. Chronic stress has a causal relationship with the hyperactivity of HPA axis. Stress induces the over-synthesis of glucocorticoids, which will arrive at all the body containing the brain. It is still complicated ...

Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, Anti-human-platelet-antigen- (HPA-) 1a is the mos...

OBJECTIVE To evaluate the clinical relevance of tetrahydrobiopterin (BH4) supplementation for pregnant women with phenylketonuria (PKU)/hyperphenylalaninemia (HPA) and the possibility of treating these patients with BH4 instead of a phenylalanine (Phe)-restricted diet. METHODS Genotyping was performed on 41 patients with PKU/HPA identified by newborn screening. Evaluating the genotype accordi...