We previously showed that bovine apolipoprotein A-II (apoA-II) had antimicrobial activity against Escherichia coli and the yeast Saccharomyces cerevisiae in PBS. We have characterized here the active domain of apoA-II using synthetic peptides. A peptide corresponding to C-terminal residues Leu(49)-Thr(76) exhibited significant antimicrobial activity against E. coli in PBS, but not against S. ce...

Experimental autoimmune encephalomyelitis (EAE) serves as a model for multiple sclerosis and is considered a CD4(+), Th1 cell-mediated autoimmune disease. IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, which is thought to play an important role in the development of Th1 cells and can exacerbate EAE. We induced EAE with myelin oligodendrocyte glycoprotein (MOG) peptide 3...

Molecular imaging is the noninvasive visualization of normal as well as abnormal cellular processes at a molecular or genetic level of function. It is used to provide characterization and measurement of biological processes in living animals and humans (in vivo). The discipline of molecular imaging evolved rapidly over the past decade through the integration of cell biology, molecular biology a...

bronchoalveolar lavage fluid proteins in sarcoidosis: a proteomics approach. Eur Respir J 2003; 21: 414–420. 8 Chang WC, Hsu PI, Chen YY, et al. Observation of peptide differences between cancer and control in gastric juice. Proteomics Clin Appl 2008; 2: 55–62. 9 Petricoin EF, Belluco C, Araujo RP, et al. The blood peptidome: a higher dimension of information content for cancer biomarker discov...

SacY is the prototype of a family of regulatory proteins able to prevent transcription termination. It interacts with a 29 nucleotide RNA sequence able to fold into a stem-loop structure and partially overlapping with a terminator sequence located in the 5' leader mRNA region of the gene it controls. We show here that the N-terminal fragment of SacY, SacY(1-55), and the corresponding fragments ...

BACKGROUND AND OBJECTIVES Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. METHODS For EAE induction, female C57BL/6 (susceptible strain) and CD1 (resistant out...

OBJECTIVE To compare the concentration of plasma atrial natriuretic peptide in patients with acute myocardial infarction with a healthy population and to determine whether a raised concentration of plasma atrial natriuretic peptide at admission was a predictor of mortality after acute myocardial infarction. DESIGN Patients with acute myocardial infarction were divided into a group with no con...

Multiple sclerosis (MS) is an auto-inflammatory disease of the central nervous system (CNS), affecting over 400,000 people in the US. MS is primarily studied in the animal model experimental autoimmune encephalomyelitis (EAE). MS is a T cell mediated disease but there is mounting evidence for a role for B cells in MS. Previous studies have established that rMOG Induction depends on the presence...

introduction: cleft lip and palate is a congenital anomaly occurring in 3 in 1000 live birth. one the major concern in this patient is about cleft gap and its surgical problems. several surgical and non-surgical procedures have been done to decrease this gap. they aimed to achieve the more esthetic results as well as feeding success. nasoalveolar molding (nam) is a new method for reshaping nasa...