Objective: To observe the changes in insulin resistance patients with gestational diabetes mellitus (GDM) based on detection of serum microRNA-372-3p and glucose transporter protein 4 (GLUT4) levels. Methods: We conducted a retrospective cohort study 42 who were diagnosed GDM hospitalized our hospital during period from January 2017 to December 2021 another had normal pregnancy same by collecti...

Background: Type 2 diabetes mellitus (T2DM) is non-insulin-dependent or that affects adults, and it represents 90% of diabetics occurs as a result insulin resistance defect in production. We aimed to evaluate levels adropin, insulin, lipid profile type2 patients.
 Aim: The current study investigate the relationship between type liver adipose tissue by measuring level secreted Hepatokines n...

Background: Diabetes is one of the most prevalent endocrine disorders in humans, and its first-line medication metformin. Peroxisome proliferator-activated receptor gamma (PPAR–γ) agonists are adjuncts to Bavachinin a PPAR pan-agonist with fewer side effects than metformin" into PPAR–γ agonists. In this study, synergistic metformin were investigated on type II diabetic rats. Methods: After four...

The in situ measured average outdoor absorbed dose rate in air was found to vary from 108.4 to 1596.4 nGy h at Homa Mountain area in southwestern Kenya. Rock and soil samples collected gave average values of the radioactivity concentrations of K, Ra and Th of 915.6, 195.3 and 409.5 Bq kg, respectively. The range of the annual effective dose for a person living in Homa Mountain area calculated v...

Abstract Background In rheumatoid cachexia (RC), high resting energy expenditure (REE) is associated with loss of muscle mass driven by proinflammatory cytokines. The objectives this study were to investigate parameters RC and the interaction between systemic inflammation modifiable risk factors for on REE. Methods Thirty‐five arthritis (RA) 19 non‐RA controls comparable in age/sex/race/body in...

OBJECTIVE We sought to examine the distribution of insulin and homeostasis model assessment of insulin resistance (HOMA-IR) and associations of HOMA-IR with sex, race/ethnicity, age, and weight status, as measured by BMI, among U.S. adolescents. RESEARCH DESIGN AND METHODS Of 4,902 adolescents aged 12-19 years who participated in the National Health and Nutrition Examination Survey 1999-2002,...

BACKGROUND/AIMS Lipid profile and insulin resistance (IR) are associated with hepatitis C virus (HCV) and may predict the chronic hepatitis C (CHC) treatment response. The aim of this study was to determine the association between CHC treatment response and lipid profile and IR change during treatment. METHODS In total, 203 CHC patients were reviewed retrospectively between January 2005 and D...

BACKGROUND The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. OBJECTIVES To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR ind...

BACKGROUND We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats. METHODS Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, a...

Glycemic disorders resolve following Roux-en-Y gastric bypass (RYGB) surgery, but early and longer-term mechanisms regarding effects on β-cell dysfunction as well as relationships with decreasing adiposity are not well understood. We evaluated longitudinal changes in peripheral insulin sensitivity (Si), the acute insulin response to glucose (AIRg), and the composite estimate of β-cell function,...