Nuclei isolated from rat liver, when incubated with methyl-labeled S-adenosylmethionine, incorporated label into 2'-O-methyladenosine, 2'-O-methylguanosine, 2'-O-methyluridine, and 2'-O-methylcytidine of endogenous nuclear RNA. Addition of ribosomal RNA from wheat germ to the reaction markedly stimulated 2'-O-methylation of total RNA. The relative incorporation of label into the four different ...

Such optimism would have struck some people as foolish at any time, but after the London bombings of 7 July and the abortive bombings of 21 July, it must strike many more as completely misguided. In particular, the fact that most of the individuals involved were born and/or brought up in Britain – a country that had given them or their parents a refuge from persecution, fear or poverty and a gu...