two simple protocols for the synthesis of tetrahydrobenzo[a]xanthenes-11-ones using nano silica phosphoric acid are reported. short reaction times, high yields, reusability of catalyst and easy workup are some advantages of these protocols.

A number of SO3H-functionalized solids (biochar, montmorillonites, carbon and halloysite nanotubes) has been studied as catalysts in the cascade Prins-Ritter reaction (-)-isopulegol with benzaldehyde acetonitrile for synthesis octahydro-2H-chromene amides (as 4R- 4S-isomers). high selectivity to these products at 30 °C presence H2O was observed on modified chlorosulfonic acid (CSA) reaching 84%...

In the title compound, C(15)H(14)O(5), an intramolecular O-H⋯O hydrogen bond occurs. In the crystal, the molecules form inversion dimers linked by pairs of O-H⋯O bonds, which are further linked by C-H⋯O interactions.

The asymmetric unit of the title compound, C11H11NO4, contains two mol-ecules, A and B, with different conformations: in mol-ecule A, the norborne and carb-oxy-lic acid groups lie to the same side of the heterocycle, whereas in a mol-ecule B, they lie on opposite sides. In the crystal, the A mol-ecules form R 2 (2)(8) carb-oxy-lic acid inversion dimers, linked by pairs of O-H⋯O hydrogen bonds. ...

The 8000 X g pellet of rabbit placenta transformed arachidonic acid into a number of lipoxygenase and cyclooxygenase products of known structure. A metabolite was also produced which was inhibited by indomethacin and required calcium for its formation. This compound had a UV absorption maximum at 227 nm under acidic or neutral conditions and gave a bathochromic shift to 281 nm under alkaline co...

The de novo design of molecules from scratch with tailored biological activity is still the major intellectual challenge in chemical biology and drug discovery. Herein we validate natural-product-derived fragments (NPDFs) as excellent molecular seeds for the targeted de novo discovery of lead structures for the modulation of therapeutically relevant proteins. The application of this de novo app...

The objectives of this research was to determine the chemical composition of roscoe extract from methanol and evaluation of antibacterial activity. The phytochemical compound screened by GC-MS method. Forty eight bioactive phytochemical compounds were identified in the methanolic extract of Zingiber officinale. The identification of phytochemical compounds is based on the peak area, retention t...

In this work, the compound 2 named ethyl (1,1-dichloro-1a,5,5,7-tetramethyl-8-oxo-1a,2,3,4,5,5a,8,9-octahydro-1H-benzo[a]cyclopropa[b][7]annulen-6-yl)glycinate (C20H29Cl2NO3) was synthesized from ?,?-unsaturated sesquiterpene ketone 1 using azido-Schmidt reaction catalyzed by titanium tetrachloride (TiCl4). The structure of newly enaminone fully identified its HRMS, FT-IR, UV-Visible, NMR (1H &...

The title mononuclear copper(II) complex, [Cu(C(7)H(6)ClN(4)O(2))(2)(H(2)O)(2)]·2H(2)O, based on 8-chloro-theophylline (HCt), has the Cu atom at a center of symmetry in a slightly distorted trans square-planar geometry coordinated by two N atoms of two deprotonated HCt ligands and two O atoms of water mol-ecules. The crystal packing is stabilized by hydrogen bonds involving deprotonated HCt lig...

Photostability of moxifloxacin (MOXI) after UVA irradiation in solutions and solid phase, with and without participation of Cu(II), Zn(II), Al(III), and Fe(III) was tested. The studies were carried out by the TLC-densitometric method and LC-MS/MS method. Elaborated and validated chromatography-densitometric method was used for assaying. It was shown that the number and type of photoproducts dep...