Model Accuracy Assessment (MAA) is an important part of the modern verification and validation process. This involves not only evaluation of a validation metric comparing experimental versus simulation system response quantities, but also the determination of the adequacy of the model for its intended use (see [1] for a detailed description). We describe here some issues related to the use of p...

Exposures to sufficiently high doses of ethylene glycol monomethyl ether (2-methoxyethanol, 2-ME) have been found to produce developmental effects in rodents and nonhuman primates. The acetic acid metabolite of 2-ME, 2-methoxyacetic acid (2-MAA), is the likely toxicant, and, as such, an understanding of the kinetics of 2-MAA is important when assessing the potential risks to humans associated w...

Poly(ethylene glycol) dimethacrylate (PEGDMA) and methacrylic acid (MAA) based micro and nanoparticles were prepared for oral insulin delivery. The reactional profiles of MAA, PEGDMA and PEGDMA-MAA were elucidated using molecular mechanics energy relationships (MMER) in vacuum and in a solvated system by exploring the spatial disposition of different concentrations of polymers with respect to e...

IMPORTANCE Quality and safety of eyedrop use for patients treated in a health care setting play a vital role in the delivery of health care. OBJECTIVE To describe the development of a policy and procedural approach to the use of multidose eyedrops in multiple patients, approved and accepted by The Joint Commission in compliance with preferred practice standards in ophthalmology, the safe hand...

Methylene blue is highly toxic and releases from various industries. It must be transformed into less compounds. The Core-Shell microgels p (Pst core), Pstcore-NIPMamm-MAa Ag in Pst-p NIPMamm-MAa have been synthesized using the hybrid micro gelling emulsion polymerization process. 0.086mM, MB 6.2mM NaBH4 0.2916 mg / mL catalysts cuvette were measured UV-visible spectrophotometers. Spectrums at ...

With the aid of theoretical calculations, a series of molecularly imprinted polymers (MIPs) were designed and prepared for the recognition of dicyandiamide (DCD) via precipitation polymerization using acetonitrile as the solvent at 333 K. On the basis of the long-range correction method of M062X/6-31G(d,p), we simulated the bonding sites, bonding situations, binding energies, imprinted molar ra...

The immunoglobulins expressed by chronic lymphocytic leukemia (CLL) B cells are highly restricted, suggesting they are selected for binding either self or foreign antigen. Of the immunoglobulin heavy-chain variable (IGHV) genes expressed in CLL, IGHV1-69 is the most common, and often is expressed with little or no somatic mutation, and restricted IGHD and IGHJ gene usage. We found that antibodi...

Penangkapan non-osseous pada pemeriksaan sidik tulang dengan menggunakan radiofarmaka Technetium-99m methylene diphosphonate (Tc-99m MDP) dapat disebabkan karena proses neoplasma, trauma, inflamasi, iskemik, dan artefak. Perubahan metabolisme lesi diketahui pencitraan Tc-99m MDP. Lesi jaringan lunak terlihat adanya peningkatan aktivitas area fokal. Tujuan penulisan telaah pustaka ini adalah unt...

It has long been a quest in ruminants to understand how two very similar mycobacterial species, Mycobacterium avium ssp. paratuberculosis (MAP) and Mycobacterium avium ssp. avium (MAA) lead to either a chronic persistent infection or a rapid-transient infection, respectively. Here, we hypothesized that when the host immune response is activated by MAP or MAA, the outcome of the infection depend...