PURPOSE: The suitability of 99mTc-diethylenetriaminepentaacetic acid (DTPA) and 99mTc-sulphur colloid (99mTc-SC) as tracers in gamma Scintigraphy for the evaluation of colon-specific drug delivery systems was assessed in healthy volunteers. METHOD: Sodium chloride core tablets containing either 99mTc-DTPA or 99mTcSC were prepared and compression coated with two different quantities of guar gum....

UNLABELLED The aim of this study was to elucidate the clinical usefulness of scatter correction with an artificial neural network (ANN) in 99mTc and 123I dual-isotope SPECT. METHODS Two algorithms for ANN scatter correction were tested: ANN-10 and ANN-3 employing 10 and 3 energy windows for data acquisition, respectively. Three patients underwent myocardial or brain SPECT with one of the foll...

99mTc complex of hexamethylpropylene amine oxime (99mTc-HMPAO), which has been used as a tracer for regional cerebral blood flow (rCBF), has been shown to localize in primary brain tumors with wide spectrum of its uptake. The causes of the wide spectrum of tumor uptake, however, has not been understood in detail. We performed autoradiographic study with this agent to get further knowledge about...

Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) is a liver scintigraphy agent which binds to asialoglycoprotein receptor in hepatocyte. Twenty-six patients with liver dysfunction were examined with 99mTc-GSA liver scintigraphy using two-compartment and two-parameter model (2C2P model). The 99mTc-GSA was assumed to move within two compartments (whole ...

Neogalactosyl albumin (NGA) is a synthetic ligand to the asialoglycoprotein receptor (hepatic binding protein), which has been proposed as a useful receptor binding radiopharmaceutical for the noninvasive assessment of liver function. We have compared the uptake and intracellular processing of iodine-125- (125I) and technetium-99m- (99mTc) NGA following its administration as a 1-min pulse (147 ...

Radiopharmaceuticals used in standard nuclear medicine for patients with breast cancer are a well-known source of ionizing radiation, emitating gamma-photon particles: tumorotroponin cationic complexes such as 99mTc-Sestamibi/ Tetrofosmin (MIBI/TF); radiolabelled somatostatin analogues 111In-Ocrteoscan/99mTc-Tektrotyd; 99mTc-MDP; 99mTc-Nanocoll and etc. The intensive tracer uptake of the differ...

The in vitro viability, chemotaxis, and labeling stability of leukocytes labeled using 99mTc-exametazime stabilized with methylene blue were evaluated and compared with those obtained using nonstabilized 99mTc-exametazime. Methods: Two identical leukocyte populations, from 30 healthy donors, were labeled simultaneously using freshly prepared and 2-h-old stabilized 99mTc-exametazime. The followi...

UNLABELLED The purpose of this investigation was to develop and evaluate a new and rapid miniaturized chromatography system that would accurately assess the radiochemical purity of 99mTc-tetrofosmin without the problems of solvent ratios and time requirements associated with the manufacturer's recommended procedure. METHODS The migration of the radiochemical components of 99mTc-tetrofosmin wa...

Introduction: Various radiopharmaceuticals, including 67Ga, 201Tl, and 99mTc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mTc-Tetrofosmin, a lipophilic cationic radiotracer, and 99mTc-sestamibi have also been reported to accumulate in thyroid tumors. In this study, we evaluated the role of 99mTc-Tetrofosmin in the differentiation of malignant from ben...

Abstract Funding Acknowledgements Type of funding sources: Other. Main source(s): Pfizer Research Grant (ID#57165999). Background Transthyretin amyloid (ATTR) cardiomyopathy continues to be considered a rare disease; however, it is now more frequently diagnosed, partly due advances in imaging techniques. Application hybrid technique single-photon emission computed tomography and (SPECT/CT) prov...