Background Premenstrual syndrome (PMS) is one of the most common problems in women of childbearing age that often interferes with their work and social relationships. The aim of the present study was to evaluate the pharmacological and non-pharmacological strategies in the treatment of PMS. Materials and Methods<...

OBJECTIVE Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance greatly limits the clinical therapeutic efficacy of TRAIL. Elucidating the molecular mechanism underlying TRAIL resistance will be fundamental to resolving this problem. METHODS Nuclear and cytoplasmic protein extraction and immuno？uorescence (IF) assay were used to detect changes in heterogeneous nuclear rib...

BACKGROUND Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disorder. Although the pathogenesis of disease is unclear, it is well known that T cells play a major role in both development and perpetuation of RA through activating macrophages and B cells. Since the lack of TNF-Related Apoptosis Inducing Ligand (TRAIL) expression resulted in defective thymocyte apoptosis leading to a...

abstract background: premenstrual syndrome (pms) can cause problems in daily work and relationships. materials and methods: eighty‑six women were randomly assigned to two intervention groups and one control group. patients were asked to fill out the pms daily symptoms record for 2 months, and then the participants were randomly assigned to one of the three study groups. medical intervention was...

abstract backgrounds: subacromial impingement is a common cause of shoulder pain and many patients with this condition recover with conservative management. the most commonly used modalities of nonoperative treatment include activity modification, anti-inflammatory medication and subacromial injection of steroid and ultrasound and physical therapy programs. this study assessed the value of phys...

background: this study aimed to assess the effectiveness of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (ocd) as an adjunct to serotonin reuptake inhibitors (sris). materials and methods: thirty-eight patients with refractory ocd, were randomly assigned to receive topiramate or placebo. this study was designed as a 12-week, double...

Poor pharmacokinetics and resistance within some tumor cell lines have been the major obstacles during the preclinical or clinical application of TRAIL (tumor-necrosis-factor (TNF)-related apoptosis-inducing ligand). The half-life of TRAIL114-281 (114 to 281 amino acids) was revealed to be no more than 30 minutes across species. Therefore maleimido activated PEG (polyethylene glycol) and MMAE (...

background: this study compares the efficacy of fluoxetine (serotonin-selective reuptake inhibitors-ssri) with doxepin (tricyclic antidepressants –tcas- antihistaminic) in treatment of irritable bowel syndrome (ibs). methods: this randomized clinical trail recruited 200 patients who had referred to kermanshah imam reza hospital during the period 2006-7. all the patients had been diagnosed with ...

Colorectal carcinoma (CRC) constitutes a common malignancy with limited therapeutic options in metastasized stages. Mesenchymal stem cells (MSC) home to tumours and may therefore serve as a novel therapeutic tool for intratumoral delivery of antineoplastic factors. Tumour necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) which promises apoptosis induction preferentially in tumour ...

Tumor necrosis-factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF-superfamily that selectively induces apoptosis through death receptors (DRs) 4 and/or 5 in cancer cells. These receptors are expressed on the cancer cell surface, without affecting normal cells. Unfortunately, many clinical studies have shown that cancer cells acquire TRAIL-resistance and finally avoid ...