We present ABCD, an integrated drug discovery informatics platform developed at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. ABCD is an attempt to bridge multiple continents, data systems, and cultures using modern information technology and to provide scientists with tools that allow them to analyze multifactorial SAR and make informed, data-driven decisions. The system cons...

A rational Diophantine m-tuple is a set of m nonzero rationals such that the product of any two of them is one less than a perfect square. In this paper we characterize the notions of regular Diophantine quadruples and quintuples, introduced by Gibbs, by means of elliptic curves. Motivated by these characterizations, we find examples of elliptic curves over Q with torsion group Z/2Z × Z/2Z and ...

BACKGROUND AND PURPOSE Some clinical models, like California ABCD and unified ABCD2 scores, are now available to predict the early risk of stroke after a TIA. Despite the transitivity of symptoms, DWI identified an area of acute brain ischemia in almost half of patients. It would be interesting to know how the presence of DWI abnormalities relates to clinical risk scores to plan other prognosti...

BACKGROUND The ABCD (Asymmetry, Border, Color, and Dimension) criteria represent a commonly used clinical guide for the diagnosis of early melanoma. The authors revised these criteria in the light of objective measurements of the features of pigmented skin lesions obtained by telespectrophotometric analysis (TS) in the visible and near-infrared wavelengths. METHODS This study involves a conse...

We show that the inclusion of a term CabcdC abcd in the action can remove the recently described anisotropic singularity occurring on the hypersurface F (φ) = 0 of scalar-tensor theories of gravity of the type