Ankle-brachial index (ABI) is an accurate tool to diagnose peripheral arterial disease. The aim of this study was to evaluate whether ABI is also a good predictor of renal outcome and cardiovascular events in patients with chronic kidney disease (CKD). We enrolled 436 patients with stage 3-5 CKD who had not been undergoing dialysis. Patients were stratified into two groups according to the ABI ...

BACKGROUND Much is known about survival after traumatic brain injury (TBI), yet relatively little about survival after anoxic brain injury (ABI). OBJECTIVE To determine whether long-term survival after ABI is comparable to that after TBI. METHODS We identified 237 patients with ABI and 1,620 with TBI in California who were aged 15 to 35, survived at least 1 year post injury, and were injure...

We read with interest the article by Al-Thani et al. [1] reporting a very low frequency (2.6%) of peripheral arterial disease (PAD) in people with acute coronary syndrome in a multicenter study conducted in sixMiddle Eastern countries. A recent multicenter study in Turkey showed 20% prevalence of PAD in people with established cardiovascular disease or who were at risk for atherosclerotic disea...

Dear Editor, We have read the article ‘‘Ankle-brachial index as a predictor of coronary disease events in elderly patients submitted to coronary angiography’’ by Eduardo D. E. Papa et al. (1). These authors aimed to evaluate the value of the ankle-brachial index (ABI) as a marker of cardiovascular events in elderly patients and to evaluate the relationship between the ABI and the extent of coro...

BACKGROUND Excluding a vascular origin of exercise-related pain is often difficult in clinical practice. Recent papers have underlined the frequent association of concurrent lumbar spine degenerative disease and peripheral arterial disease. Furthermore, even when suspected, isolated exercise-induced proximal ischemia is difficult to diagnose. Measurement of transcutaneous oxygen pressure (tcpO2...

OBJECTIVE To study the relationship between the presence of peripheral artery disease (PAD) and the morbidity and mortality at 6 years, and the ankle-brachial index (ABI) as a predictor of morbidity and mortality in type 2 diabetes mellitus. DESIGN Retrospective cohort study. Six years follow-up. SETTING Urban health centre. PARTICIPANTS A total of 269 type 2 diabetics, of which 63 had PA...

BACKGROUND Prediction of major cardiovascular and cerebrovascular events using conventional risk factor models is limited. Noninvasive measures of subclinical atherosclerosis such as the ankle brachial index (ABI) could improve risk prediction and provide more focused primary prevention strategies. We wished to determine the added value of a low ABI in the prediction of long-term risk of cardio...

Microtubules are critical components of the cytoskeleton. Perturbing their function arrests the growth of a broad spectrum of cancer cell lines, making microtubules an excellent and established target for chemotherapy. All of the U.S. Food and Drug Administration-approved antitubulin agents bind to paclitaxel or vinblastine binding sites in tubulin. Because of the complexity of their structures...

Background: Peripheral artery disease (PAD), indicated by abnormal ankle-brachial index (ABI), and metabolic syndrome (MetS) have been implicated as critical risk factors for increased cardiovascular mortality. However, data establishing associations between abnormal ABI and MetS are conflicting and few have examined the role of additional cardiovascular risk factors. The aim of this study is t...