A. W. Siegel* and J. M. C. Schraagen Department of Cognitive Psychology and Ergonomics, University of Twente, Enschede, Netherlands TNO Earth, Life, and Social Sciences, Soesterberg, Netherlands OCCUPATIONAL APPLICATIONS This article describes an observational study at a rail control post to measure workload weak resilience signals. A weak resilience signal indicates a possible degradation of a...

A mathematical model of short-term cardiovascular regulation is used to investigate how heart period variability reflects the action of the autonomic regulatory mechanisms (vagal and sympathetic). The model includes the pulsating heart, the systemic (splanchnic and extrasplanchnic) and pulmonary circulation, the mechanical effect of respiration on venous return, two groups of receptors (arteria...

Understanding the effects of the mechanical environment on wound healing is critical for developing more effective treatments to reduce scar formation and contracture. The aim of this study was to investigate the effects of dynamic mechanical stretch on cell-mediated early wound remodeling independent of matrix alignment which obscures more subtle remodeling mechanisms. Cyclic equibiaxial stret...

Venous ulcers are a common, costly occurrence. Treatment typically includes the use of short-stretch and four-layer bandages--both with demonstrated ability to increase venous return and healing rates. Which is superior is unclear. To determine whether short-stretch bandages or four-layer compression systems provide shorter healing times and fewer adverse events when used in adults with venous ...

Caveolae are invaginations of the plasma membrane that are formed by caveolins. Caveolar membranes are also enriched in cholesterol, glycosphingolipids and signaling enzymes such as Src kinase. Here we investigate the effect of cell stretch upon caveolar dynamics and signaling. Transfection of C2 myoblasts with caveolin-3-YFP led to the formation of caveolae-like membrane pits 50-100 nm in diam...

BURNSTOCK, GEOFFREY AND C. L. PROSSER. Responses of smooth muscles to quick stretch; relation of stretch to conduction. Am. J. Physiol. rg8(5) : g21--93:s. I g6o.-Quick stretches applied to isolated strips of visceral muscles elicit contractions and electrical responses, similar stretches elicit no responses from blood vessels and nictitating membrane. Highly excitable muscles gave repetitive r...

Myocardial stretch, as result of acute hemodynamic overload, is one of the most frequent challenges to the heart and the ability of the heart to intrinsically adapt to it is essential to prevent circulatory congestion. In this review, we highlight the historical background, the currently known mechanisms, as well as the gaps in the understanding of this physiological response. The systolic adap...

The flight muscles of many insects have a form of regulation enabling them to contract at high frequencies. The muscles are activated by periodic stretches at low Ca2+ levels. The same muscles also give isometric contractions in response to higher Ca2+. We show that the two activities are controlled by different isoforms of TnC (F1 and F2) within single myofibrils. F1 binds one Ca2+ with high a...

background: the herpes simplex virus (hsv) ul41 gene product, virion host shutoff (vhs) protein, mediates the rapid degradation of both viral and cellular mrna. this ability suggests that vhs protein can be used as a suicide gene in cancer gene therapy applications. the recent reports have shown that the degradation of cellular mrna during herpes simplex infection is selective. rna containing a...