BACKGROUND This study was done to evaluate the visual and anatomical outcomes of topical regenerating agents as a novel therapy for neutrophic corneal ulcer (NCU) secondary to acanthamoeba infection. FINDINGS A 20-year-old woman with a history of contact lens wear was referred to our hospital for keratitis after responding poorly to conventional treatment. In vivo confocal microscopy images s...

Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated, manageable treatments. Hexadecylphosphocholine (miltefosine) is licensed for...

Keratitis due to Acanthamoeba is a potentially sight threatening condition if unrecognised, or if inappropriate medical therapy is used.' The infection is being recognised worldwide.'A It is often associated in Europe and in the USA with contact lens wear; elsewhere, particularly in the tropics, it occurs most often in rural communities and can be associated with trauma and mud splashing.5 We p...

Keratitis due to Acanthamoeba is a potentially sight threatening condition if unrecognised, or if inappropriate medical therapy is used.' The infection is being recognised worldwide.'A It is often associated in Europe and in the USA with contact lens wear; elsewhere, particularly in the tropics, it occurs most often in rural communities and can be associated with trauma and mud splashing.5 We p...

Acanthamoeba keratitis (AK) is a vision-threatening corneal infection that most frequently affects contact lens wearers. Severe pain out of proportion to the findings, radial keratoneuritis, and ring infiltration are relatively specific clinical manifestations AK. The diagnosis AK challenging it often misdiagnosed because atypical presentations. definitive requires presence cysts or trophozoite...

Acanthamoeba keratitis is a chronic inflammatory disease of the cornea which is highly resistant to many antimicrobial agents. The pathogenic mechanisms of this disease are poorly understood. However, it is believed that the initial phases in the pathogenesis of Acanthamoeba keratitis involve parasite binding and lysis of the corneal epithelium. These processes were examined in vitro, using Aca...

An outbreak of Acanthamoeba keratitis, a rare, potentially blinding, corneal infection, was detected in the United States in 2007; cases had been increasing since 2004. A case-control study was conducted to investigate the outbreak. We interviewed 105 case-patients from 30 states and 184 controls matched geographically and by contact lens use. Available contact lenses, cases, solutions, and cor...

Keratitis due to Acanthamoeba is a potentially sight threatening condition if unrecognised, or if inappropriate medical therapy is used.' The infection is being recognised worldwide.'A It is often associated in Europe and in the USA with contact lens wear; elsewhere, particularly in the tropics, it occurs most often in rural communities and can be associated with trauma and mud splashing.5 We p...