1 wo previous reports have demonstrated dual AV nodal pathways as the causative mechanism of spontaneous SVT termination in the WPW syndrome. Westveer et al’ reported a patient with WPW and non-sustained antidromic SVT, where SVT termination was related to retrograde dual AV nodal pathways. Retrograde conduction of the SVT occurred over the slow retrograde AV nodal pathway with concealment into...

OBJECTIVES The primary objectives of this study were to assess the feasibility of temperature-controlled radiofrequency catheter ablation of left and right sided manifest accessory pathways in patients with Wolff-Parkinson-White syndrome and to gain more insights into biophysical aspects of temperature-controlled catheter ablation in humans. BACKGROUND The electrode-tissue interface temperatu...

Activation of the JNK/activator protein-1 (AP-1)-signaling pathway is a common mediator of hepatocyte death from a variety of stimuli. Although the mechanism by which JNK or AP-1 promotes death is unknown, it results when activation of this signaling pathway is unusually prolonged. Although JNK/AP-1 mediates TNF-induced cell death at or above the level of the mitochondria, the ability of JNK/AP...

I Wellens HJJ, Brugada P, Penn OC, Gorgels AP, Smeets J. Pre-excitation svndromes: clinical presentation, course and therapy. In: Zipes DP, Jalife J, eds. Cardiac electrophvsiology: from cell to bedside. Philadelphia: W B Saunders, 1990:691-702. 2 Klein GJ, Bashore TM, Sellers TD, Pritchett ELC, Smith WM, Gallagher JJ. Ventricular fibrillation in the Wolff-Parkinson-White syndrome. N Engl3' Med...

BACKGROUND Several investigators have recently ablated electrophysiologically mapped accessory connections in the adult human myocardium by using radiofrequency current. To examine the effectiveness and safety of radiofrequency current for ablation of accessory connections in children, 20 consecutive patients (age, 3-18 years) with preexcitation and/or supraventricular tachycardia were evaluate...

This patient has an arrhythmia with orthodromic circus movement tachycardia and dual AV-nodal pathways. In addition, the ECG shows a Brugada pattern. The resting ECG (Fig. 1a) shows sinus rhythm and a type 2 Brugada pattern. The 12-lead ECG during arrhythmia (Fig. 1b) shows a narrow QRS rhythm, 88 bpm (cycle length: 680 ms) with a 1:1 AV ratio. The P waves are narrow and inverted in leads II, I...

INTRODUCTION Short accessory pathway (AP) effective refractory period (ERP) is one of the risk factors in Wolff-Parkinson-White syndrome (WPW). The purpose of study was to evaluate the reproducibility of APERP measurement during a same electrophysiological study (EPS). METHODS EPS consisted of 2 APERP measurements performed prospectively in 77 patients for a WPW in control state (CS) at a cyc...

Electrical stimulation of the dog's area postrema (AP) induces a response that mimics the pressor response produced by intravertebral infusion of low-dose angiotensin II, which causes an increase in mean arterial pressure associated with transient tachycardia and increased peripheral resistance. The present study investigated in morphine-chloralose anesthetized dogs whether: 1) the characterist...

Nineteen procedures were performed in 17 children, aged 10 months to 17 years, using catheter radiofrequency applications for the management of malignant or drug-resistant supraventricular tachyarrhythmias. Diagnoses were junctional ectopic tachycardia in 1 patient, atrioventricular (AV) node reentrant tachycardia in 4 and accessory pathway-mediated tachycardia in 12. Accessory pathway location...

We report the case of a patient followed since childhood for congenital complete atrioventricular block. At 28 years of age, atrioventricular conduction through an accessory pathway with long conduction times was detected. Periods of atrioventricular conduction alternated with periods of atrioventricular block. Sinus tachycardia and 1:1 exclusive conduction through the accessory pathway develop...